Re: SHBG
From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Wed, 18 Jul 2001 19:26:23 +0200
Hi Carol,
Theoretically it is true that low estrogens cause low SHBG, but it may not be true for PCOS, because the problem with most PCOSers is estrogen aboundance, so I do not see the reason giving extra estrogens. But lowering your androgens definitely increases SHBG.
References would be welcome (attached file or similar)
Sam
> Hi Sam,
> Thank-you for the more detailed answer to my question about SHBG, I was
> confused from your last answer, you did not specify that the injections
> wouldn't help any. My doctor told me to take estrogen because its
> abundance is linked to higher SHBG and therefore less free testosterone.
> Is this incorrect? As for the relationship between insulin resistance,
> depression and SHBG, I got those from reading the Journals of Medicine
> and reading a couple of new books about PCOS. I think (!)I've been
> fairly careful to go to reputable sources. Would you like some
> references?
>
> Thanks,
> Carol
>
> At Tue, 17 Jul 2001, =?iso-8859-2?q?Zalányi wrote:
> >
> > Hi Carol,
> >
> >I have answered this a week ago. I do not know of any SHBG injections and
> >there is no reason to have it. SHBG may be low in PCOSers not because of
> >insulin resistence but because of elevated androgens. It would be futile to
> >have it injected because it would be destroyed as all other proteins are,
> >but if your androgens are lowered, SHBG will increase automatically. I do
> >not know of a link between SHBG, depression and IR (my ignorance?). Would
> >you clarify please.
> >By the way, why would you take estrogens for PCOS?
> >Looking forward to your answer
> >
> >Sam
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