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Re: SHBG

From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Tue, 17 Jul 2001 21:04:37 +0200


Hi Carol,

I have answered this a week ago. I do not know of any SHBG injections and there is no reason to have it. SHBG may be low in PCOSers not because of insulin resistence but because of elevated androgens. It would be futile to have it injected because it would be destroyed as all other proteins are, but if your androgens are lowered, SHBG will increase automatically. I do not know of a link between SHBG, depression and IR (my ignorance?). Would you clarify please. By the way, why would you take estrogens for PCOS? Looking forward to your answer

Sam

> Does anyone know if injections of SHBG are a future possibility? I am
> one of those people who can't take the BCP or estrogen due to migraines
> so this PCOS is running wild. From all my research, I have learned that
> SHBG is an extremely important yet little known protein. Low SHBG is
> linked with insulin resistance related disorders (PCOS and diabetes) and
> also with depression (sound familiar to anyone?!). The same
> neurotransmitters are involved in depression and diabetes. Apparently,
> SHBG needs to be in balance - having too much of this protein is linked
> to increased risk for osteoporosis. So, at least one small mercy in
> this hell that we suffer is that we might be at a lower risk for bone
> density problems. I've learned more but that's enough for now. Can
> anyone add to my knowledge about SHBG? Perhaps a docor even.
>




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