PCOS-MEDICATION Messages for July, 2001: Re: Yet another question about insulin sensitizers

Re: Yet another question about insulin sensitizers - Dr. Sam

From: Margot (anonymous@obgyn.net)
Sun, 1 Jul 2001 12:00:47 -0500 (CDT)

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Mel,

Here's my thinking on the matter, and if my reasoning doesn't seem sound, just ignore me. And excuse my redunancy but I have to work through this logically for it to make sense.

Here we go: We PCOSers are insulin resistant. Our bodies' receptors are not sensitive to "normal" amounts of insulin in the blood stream. So, in response, the pancrease pumps out more insulin, hence all of our other fun problems. When you start on a glucophage (metformin or whatever), it makes your body more sensitive to the acutal levels of insulin flowin' through your blood stream, right? So, the insulin is suddenly being made more effective but the pancrease hasn't caught up yet. And what does insulin do for ours bodies? It burns glucose. Therefore, with the insulin suddenly be more effective it is burning more sugar... and wouldn't that produce the symptoms you described below (hypoglycemia, etc)?

I think that works. And, therefore, what everyone is saying (incl. Dr. Glueck) is true, the drug does not directly reduce blood sugar levels... but it indirectly causes lower blood sugar levels, at least until the pancrease starts producing less insulin. Make sense?

Possible solution?: munch throughout the day to maintain blood sugar levels... maybe.

And, on that note, I'm going to my kitchen to find some celery. I just started Met and am currently feeling a bit shaky...

~Margot

>So. My original question was "Why would Dr. Sam and others suggest
>that my strange reaction to Metformin (extreme fatigue and weakness)
>was hypoglycemia if, according to Glueck and info from the makers of
>this drug, the drug does not lower blood glucose?" Hypoglycemia by
>definition means "low blood glucose". I have tested negative (many
>times) for hypoglycemia and diabetes. The reaction I had was
>definitely from the Metformin, it was not a coincidence, as I never had
>it before taking it, and I have never had it since taking it.

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