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Re: Yet another question about insulin sensitizers - Dr. SamFrom: Melinda (anonymous@obgyn.net)Wed, 27 Jun 2001 13:14:01 -0700 (PDT)
--- Zowie <anonymous@obgyn.net> wrote: > Metformin and Avandia DO lower blood sugar, that's why they're so > commonly prescribed to diabetics (in connection with the fact that > they > are insulin sensitizers). I'm not trying to be argumentative, but from everything I have read (and I've read a lot), the whole thing that makes drugs like Metformin and Avandia different is that they work on excess insulin in the body, rather than working directly on blood glucose. We PCOSers, as I understand it, produce too much insulin because our cells are resistant to insulin that is already there, and our bodies mistakenly think they need to make more. Many of us can have test after test that show our blood glucose levels to be normal, yet we still produce too much *insulin*. Insulin-sensitizing drugs (like Met and Avandia) work on using the insulin that your body produces, and they are safe for people who don't have high blood glucose to take, because they do NOT lower blood glucose. I don't care for Dr. Glueck myself, but he seems to be well-respected among PCOSers, and this is from his website: "Metformin is a widely available, safe, effective drug used for treatment of adult onset diabetes. It can be given safely to subjects with normal blood glucose levels because it will not lower them." So. My original question was "Why would Dr. Sam and others suggest that my strange reaction to Metformin (extreme fatigue and weakness) was hypoglycemia if, according to Glueck and info from the makers of this drug, the drug does not lower blood glucose?" Hypoglycemia by definition means "low blood glucose". I have tested negative (many times) for hypoglycemia and diabetes. The reaction I had was definitely from the Metformin, it was not a coincidence, as I never had it before taking it, and I have never had it since taking it. --Mel Get personalized email addresses from Yahoo! Mail
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