Re: Dr Sam -- about Glucophage
From: =?iso-8859-2?q?Zalányi Sámuel?= (anonymous@obgyn.net)
Sat, 19 May 2001 09:26:50 +0100 (MET DST)
Dear DOna,
Surely this is a way to decrease the risks of metformin being continued during the first trimester.
For your help
Sam
> Dr sam,
> Could taking extra folic acid along with the metformin during the first
> trimester of preganacy lower the risk of spina bifida?Thus making
> metformin safer?
> thanks,Dona
>
> >At Fri, 18 May 2001, =?iso-8859-2?q?Zalányi wrote:
> >Hi Christa,
> >
> >There is a controversy about taking glucophage during pg. Drug
> manufacturers tend to minimize the risk of their drugs being taken during
> pg, thus they set up categories for them: A is absolutely safe, B is not
> harmful, C potentially harmful and D is dangerous during pg. As there is not
> enough experience with metformin during pg they have put it into category C.
> The truth is that therer is some basis for cat. C, because metformin reduces
> the absorption of folic acid thus increasing the risk of neural tube
> defects. But stoping it during pg increases the risk of spontaneuos
> abortion. Finally you have to make a painful decision which risk is greater
> (I think the sp.ab. is).
> >For your info
> >
> >Sam
> >
> >> Hi Dr. Sam--
> >>
> >> Do you know any PCOS women that have taken Glucophage during pregnancy?
> >> I'm not trying to get pregnant right now but I will be soon. My endo
> >> says I have to stop the Gluco as soon as I do become pregnant but I have
> >> many women say they chose to stay on it during pregnancy as it prevents
> >> miscarriages.
> >>
> >> Do you know if any harm can come to the fetus?
> >>
> >> Can't it be harmful to the fetus to have too much insulin racing around
> >> your blood and elevated androgens?
> >>
> >> Thanks for your time.
> >>
> >> --
> >> Christa :-)
>
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