Re: Why did it stop working? Gluc/Clomid questions...
From: =?iso-8859-2?q?Zalányi Sámuel?= (anonymous@obgyn.net)
Fri, 20 Apr 2001 03:52:35 +0100 (MET DST)
Hi Stacy,
The exact mechanism of action of clomid is still not fully understood. Suffice to say it is not dose dependent. So if you ovulated on 50 mg, you should continue on that dose. There is also a wearing off effect after several months. So give a pose to clomid and star again on 50 mg. By the way: which CDs were you taking it 5-9 or 3-7?
Looking forward to your answer
Sam (Ob/Gyn,RE)
> We have been ttc since January 2000 in vain. I finally was dx with PCOS
> in September 2000 (my doc initially laughed off my concerns about PCOS
> because I was not overweight!) and my OBGYN immediately put me on 50mgs
> clomid. For three cycles I responded (Oing on cd18, cd19, and cd20
> respectively) My SIL works for a different OBGYN who said I was Oing too
> late in my cycle and that he would like me to come in and talk with him.
> Feb 1 I went into his office. He sang the praises of the Met/Clomid
> cocktail and DH and I decided to give it a try. I started a progressive
> dose of Met (500mgs a day to start, increasing to 1500 in three weeks)
> and he bumped my clomid up to 100mgs. For the first time on clomid, I
> didn't O!!! I was heartbroken because I felt like I had taken a step
> backward, but he insisted that the Met takes awhile to work and to try
> another cycle. After a grueling 47 day cycle with no AF and a pg test
> in his office (fun!) my doc put me on Provera and I took another round
> of clomid and again...NO O!!!
> Has anyone had this happen? Should I not be taking the Met? I went to an
> Endo who said my fasting insulin was totally normal, but I didn't do any
> other insulin testing. I am only about 15 lbs overweight (mostly from
> all the junk I have stuffed myself with to "soothe" my depression). I
> just don't know what to think. I had very strong Oing for those three
> non-Met cycles (7 dpo p4 levels were above 25 all three cycles). I am
> beside myself...I am searching for someone who can help me understand
> this. We are currently taking a break from ttc, as my heart needs some
> time to heal. The doc wants me to keep taking Met but I don't want to
> do any more damage to my battered reproductive system...
>
> Any input at all is very much appreciated!!
>
> Thanks! Stacy
>
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