PCOS-MEDICATION Messages for March, 2001: Re: Question about LH, ANDROGENS and CLOMIPHENE

Re: Question about LH, ANDROGENS and CLOMIPHENE

From: Susan (anonymous@obgyn.net)
Fri, 23 Mar 2001 00:48:29 -0600 (CST)

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At Sat, 10 Feb 2001, Asad wrote: >
>Hi there
>
>I have a question regarding the pathogensis of Polycystic Ovary Syndrome
>(PCOS)
>
>I know that:
>
>-in this syndrome the woman will have very high LH levels, this causes
>maturation of ovaries,
>
>but because (in this disease) she also has high levels of ANDROGENS, she
>does not release these eggs (does not ovulate).
>
>So INFERTILITY is a common problem with this syndrome.
>
>To treat it, women are often given CLOMIPHENE, which helps increase LH
>levels to induce ovulation.
>
>But I AM VERY CONFUSED!!
>
>My question is:
>
>why are we trying to increase LH levels with Clomiphene when she already
>has high LH levels???
>
>and after giving Clomiphene, she still has high levels of androgens
>(right?), so how come now she is now able to ovulate??
>
>I would really appreciate it if someone could explain this to me
>thanks!
>
>--
>Asad Raza
>SUSOM MS II
>asad_raza@go.com
>

This is my understanding. The LH level "surges" when it is time to release an egg. Since a woman with PCOS always has a high level, there is nothing to "trigger" the release. Taking clomid artifically gives the LH level a boost and tells your ovaries to release the egg. I used clomid to get pregnant 4 yrs. ago, and I now have 2 beautiful, healthy children, Girl and Boy Twins! I understand my answer is quite simple compaired to what all is going on, but I hope this helps!

--
Susan
PCOS Mom to 3 yr. old twins

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