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Re: Spiro, Actos and Avandia--need info please
From: =?iso-8859-2?q?Zalányi Sámuel?= (anonymous@obgyn.net)
Mon, 12 Mar 2001 22:40:17 +0100 (MET DST)
Dear Zowie,
I think I have answered your question regarding spironoplactone and weight loss: spironolactone is basically a diuretic, thus you may shed some kilos when start to take it.
Actos/Avandia: although they are not available in this country yet, but they work the same way as metformin does: they are insulin sensitizers and may reduce your insulin levels and improve your carbohydrate metabolism. As they were introduced only lately, there is less experience with them than with metformin. They seem to cause less side-effects but do not reduce weight (actually some women do put on some). As metformin reduces androgen levels and hyperandrogeni symptoms (acne, hair growth, weight gain etc.) it is expected that the latest insulin sensitizers would do the same, but there is little experience as far as that.
Hope this information helps
Sam (Ob/Gyn, RE)
> Hi ladies,
> I posted these questions last week on both boards, but they quickly got
> pushed to the bottoms of the list (which we don't usually read anymore),
> so I thought I'd repost in hopes that I can get some responses. Ok,
> first--Spiro. A woman posted on the general board stating she was Rx
> spiro to lose weight. My understanding was that Spiro is simply an
> anti-androgen to help combat the cosmetic issues of PCOS (Hair, acne,
> etc.). Is it true that Spiro is also Rx for weight loss?? How does it
> work then? Second, I had to stop Met because of the horrible diarrhea,
> nausea and other side effects it was causing because it landed me in the
> ER. I have read about Actos and Avandia instead of Met and was
> wondering how they differ, both from Met and each other. I have an RE
> appt. at the end of the month and want some basic answers before
> questing him/her about my options with these. The acne has really broke
> out on me terribly the past 2 weeks and the hair is growing much faster
> and thicker. I need help! It's really getting annoying and I feel like
> I need to hide from it all. My husband constantly starts picking at my
> pimples (even though I told him I HATE when he does that) and it's like
> as if that's ALL he notices on my face. It's really bothering me and I
> need to see what meds will work for this. Any ideas would be VERY
> helpful and appreciated. (P.S. I can't do the low carb/sugar
> diets--they interfere with my hypoglycemia and the simple TRANSITION
> into it made me sick, so anything to help me lose weight--I wanna hear
> about. lol) I don't have a problem overeating, and actually our diet is
> quite healthy, but with my anemia, hypoglycemia AND PCOS--I'm not
> energetic at all and need some help. Can anyone offer some suggestions
> or answers??
>
> --
> -- Zowie :)
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