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Re: Amy, Clara, Monica,Re: Metformin anyone?
From: Laura (anonymous@obgyn.net)
Sun, 13 Aug 2000 12:18:13 -0500 (CDT)
Thank you Amy! I wish you the best of luck as well. It's nice to have
some support!
At Wed, 02 Aug 2000, Amy wrote:
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>Hi there Laura - I wish you the best of luck!!! (: Amy
>
>Laura wrote:
>
>> You all have given me hope again...thank you! I am going to my doctor on
>> the 8th and TELLING her to try me on Metformin. Are any of you in
>> Michigan? I desperately need to find an intelligent PCOS doctor here.
>>
>> At Mon, 31 Jul 2000, Amy wrote:
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>> >Hi Monica - I tolerate it okay... I am on 1000 mg per day where as I think most are on
>> >1500 mg per day ... at first I had horrible upset stomachs but now it is on and off -
>> >minimum 2 times a week.
>> >I can tell a difference as far as Met in comb with levlite (bcp) ... I am in such
>> >better emotional health ... I still have a pain occasionally in my lower abdomen (cysts
>> >I guess) but not like I had.
>> >I came to a stand still with weight loss so I am now on Xenical also ... have lost 12
>> >lbs on top of the 8 that I lost while on met/bcp alone. It took me 4 weeks to not have
>> >such horrible stomach upsets ... I do feel better emotionaly and physically as far not
>> >having horrible cramps all the time - also - I was having bouts of hypoglycemia
>> >frequently ...
>> >My bloodwork is to be monitored every 3 months as I have endometreosis, diabetes and
>> >heart disease in my immediate family ... give it a while .... I do feel so much better
>> >...
>> >Best of Luck to you!!!!! (: Amy
>> >Monica wrote:
>> >
>> >> So very interesting. It makes sense to me about Met keeping everything
>> >> even keel and how that might be the reason it works for nonIR PCOSers. I
>> >> would love to learn more about this. Amy, how have you been tolerating
>> >> the MET? My doc (a GP at my HMO) put me on MET without testing for IR.
>> >> Based upon my high testosterone, high DHEAS, obvious outward signs of
>> >> apple shape, hirsutism, and family history of diabetes, as well as
>> >> medical journal articles about PCOS that HE read, he felt MET would work
>> >> for me. So I may be IR or I may not be. At first I really wanted to
>> >> know but then I realized it wouldn't change anything and I didn't want
>> >> waste any more time. At least he wanted to give it a try for which I am
>> >> grateful. He also stressed the importance of regular exercise and a
>> >> diet filled with adequate amounts of protein, fat, and whole grains,
>> >> fruits, and veggies. So I may be IR or I may not be. At first I really
>> >> wanted to know but then I realized it wouldn't change my course of
>> >> action and I didn't want to waste any more time before beginning
>> >> treatment. I've been on MET for 6 DAYS now and so far nothing terrible
>> >> in terms of side effects, (a little cramping and gas the first few days,
>> >> and a little nausea that comes and goes in waves). I'm going to give it
>> >> at least six months. Then I'll reevaluate things.
>> >> Ooops, sorry to blather on so long! I'd love to hear how you are doing.
>> >> :)Monica
>> >>
>> >> At Mon, 31 Jul 2000, Amy wrote:
>> >> >
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>> >> >Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant ... From
>> >> >what my Doctor told me, Met helps to keep from becoming completely IR .... From
>> >> >what I have read in journals, also, is that PCOS is actually caused from Insulin
>> >> >ups and downs, not PCOS causing IR .... I have been on Met for about 3 months now
>> >> >without being IR ...so I also respectfully disagree.... The point of Met is to
>> >> >help "even Keel" everything to avoid hyper and hypoinsulinism. Hope everyone has
>> >> >a wonderful day!!! (: Amy
>> >> >
>> >> >"Avalos, Clara" wrote:
>> >> >
>> >> >> Monica...
>> >> >>
>> >> >> It's Monday morning and I am racing through posts from the weekend... been
>> >> >> following this thread with interest, though... I just wanted to send over
>> >> >> some support for your assertions... From all the reading that I have been
>> >> >> doing, I've come to pretty much the same conclusions that you write here in
>> >> >> your message below. Thanks for putting it so well!
>> >> >>
>> >> >> =o) Hugs,
>> >> >>
>> >> >> Clara
>> >> >>
>> >> >> -----Original Message-----
>> >> >> From: anonymous@obgyn.net [mailto:anonymous@obgyn.net]
>> >> >> Sent: Sunday, July 30, 2000 8:48 AM
>> >> >> To: Multiple recipients of list PCOS-MEDICATION
>> >> >> Subject: Re: Metformin anyone?
>> >> >>
>> >> >> You are entitled to your opinion. I'm basing my opinion on previous
>> >> >> posts from this forum's archives, journal articles I've read and the
>> >> >> following taken from "PCOS Frequently Asked Questions" at
>> >> >> http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
>> >> >> Information Dissemination):"... At least 30% of women with PCOS are
>> >> >> insulin resistant, although some investigators claim a much stronger
>> >> >> association exists. ...It appears that even some patients who so not
>> >> >> test as being insulin resistant may benefit from these medication. Some
>> >> >> doctors do give insulin-sensitizing medications to patients with PCOS,
>> >> >> including lean women, whether or not they test as clearly being insulin
>> >> >> resistant. Though studies are needed to firmly establish the benefit,
>> >> >> many patients appear to experience improvements in symptoms and cycling.
>> >> >> The cause of this improvement is unclear." Whether one is diagnosed as
>> >> >> IR seems to be a mute point. We know this is a progressive disease,
>> >> >> who's to say that today I'm not IR but in a few months I could be?
>> >> >> Perhaps that is why people who do not officially test positive for IR
>> >> >> still reep the benefits and relief that glucophage can provide. I'd
>> >> >> rather take that approach then continue gaining weight dispite my
>> >> >> efforts with diet and exercise and end up with type II diabetes some
>> >> >> day. True, MET is not a hormone, but you can't dismiss the effects it
>> >> >> has on hormones even in people without IR. If glucophage seems to help
>> >> >> even non-IR people, and relatively safe, then why fight it? Why is it
>> >> >> that non-IR people still have high testosterone levels and glucophage
>> >> >> helps them? I think they're still working on that one. If there's one
>> >> >> thing we *do* know, we don't know everything about this disease. I
>> >> >> believe in order to make srtides in an attempt to tackle this disease,
>> >> >> we need to be open-minded.
>> >> >> Monica
>> >> >>
>> >> >> At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
>> >> >> >
>> >> >> >And what are you citing? I was in a University of Michigan Rezulin
>> >> >> >study, one of the requirements was Insulin Resistance. Their info
>> >> >> >specifically said that only half to 3/4s of the women w/PCOS had IR. And
>> >> >> >how can the Met work on anything other than IR? For those of us with it,
>> >> >> >it's the IR that causes the testosterone dysfunction. Met's not a
>> >> >> >hormone, so I have no idea where you're getting this info.
>> >> >> >
>> >> >> >At Sat, 29 Jul 2000, Monica wrote:
>> >> >> >>
>> >> >> >>Stacey,
>> >> >> >>I respectfully disagree. The new studies show that MET is effective in
>> >> >> >>treating PCOS patients who do not show signs of insulin resistance. PCOS
>> >> >> >>manifests itslef in two ways, IR and testosterone/androgen disfunction.
>> >> >> >>The MET works on both things. I suggest before making such glib answers
>> >> >> >>you check your facts, please.
>> >> >> >>Monica
>> >> >> >>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
>> >> >> >>>
>> >> >> >>>But what do you think that Met will do for you? It's sole purpose in
>> >> >> >>>being is to fix insulin issues. That's like giving someone with a bad
>> >> >> >>>heart a new brain to fix the problem.
>> >> >> >>>
>> >> >> >>>At Thu, 27 Jul 2000, melissa wrote:
>> >> >> >>>>
>> >> >> >>>>i'm on glucophage and my doctor never checked my insulin level. We also
>> >> >> >>>>fought until he gave in. he just checked my liver and kidneys first.
>> >> >> good
>> >> >> >>>>luck, melissa
>> >> >> >>>>
>> >> >> >>>>>From: Goldsngurl@aol.com (Laura)
>> >> >> >>>>>Reply-To: pcos-medication@obgyn.net
>> >> >> >>>>>To: Multiple recipients of list PCOS-MEDICATION
>> >> >> >>>>><pcos-medication@mail.medispecialty.com>
>> >> >> >>>>>Subject: Metformin anyone?
>> >> >> >>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
>> >> >> >>>>>
>> >> >> >>>>>Hey! Is anyone currently on Metformin and not insulin resistant? I am
>> >> >> >>>>>currently head to head with my doctor, but she won't budge. Pls let me
>> >> >> >>>>>know!
>> >> >> >>>>>
>> >> >> >>>>>--
>> >> >> >>>>>Thanks!
>> >> >> >>>>>Laura
>> >> >> >>>>>
>> >> >>
>> >> >--------------2D87DD81E9879D793D00B135
>> >> >Content-Type: text/html; charset=us-ascii
>> >> >Content-Transfer-Encoding: 7bit
>> >> >
>> >> ><!doctype html public "-//w3c//dtd html 4.0 transitional//en">
>> >> >
>> >> >Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant
>> >> >.. From what my Doctor told me, Met helps to keep from becoming completely
>> >> >IR .... From what I have read in journals, also, is that PCOS is actually
>> >> >caused from Insulin ups and downs, not PCOS causing IR .... I have been
>> >> >on Met for about 3 months now without being IR ...so I also respectfully
>> >> >disagree.... The point of Met is to help "even Keel" everything to
>> >> >avoid hyper and hypoinsulinism. Hope everyone has a wonderful day!!!
>> >> >(: Amy
>> >> >"Avalos, Clara" wrote:
>> >> >Monica...
>> >> >It's Monday morning and I am racing through posts from the weekend...
>> >> >been
>> >> >following this thread with interest, though... I just wanted to send
>> >> >over
>> >> >some support for your assertions... From all the reading that I have
>> >> >been
>> >> >doing, I've come to pretty much the same conclusions that you write
>> >> >here in
>> >> >your message below. Thanks for putting it so well!
>> >> >=o) Hugs,
>> >> >Clara
>> >> >-----Original Message-----
>> >> >From: anonymous@obgyn.net [mailto:anonymous@obgyn.net]
>> >> >Sent: Sunday, July 30, 2000 8:48 AM
>> >> >To: Multiple recipients of list PCOS-MEDICATION
>> >> >Subject: Re: Metformin anyone?
>> >> >You are entitled to your opinion. I'm basing my opinion on previous
>> >> >posts from this forum's archives, journal articles I've read and the
>> >> >following taken from "PCOS Frequently Asked Questions" at
>> >> >http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
>> >> >Information Dissemination):"... At least 30% of women with PCOS
>> >> >are
>> >> >insulin resistant, although some investigators claim a much stronger
>> >> >association exists. ...It appears that even some patients who
>> >> >so not
>> >> >test as being insulin resistant may benefit from these medication.
>> >> >Some
>> >> >doctors do give insulin-sensitizing medications to patients with PCOS,
>> >> >including lean women, whether or not they test as clearly being insulin
>> >> >resistant. Though studies are needed to firmly establish the
>> >> >benefit,
>> >> >many patients appear to experience improvements in symptoms and cycling.
>> >> >The cause of this improvement is unclear." Whether one is diagnosed
>> >> >as
>> >> >IR seems to be a mute point. We know this is a progressive disease,
>> >> >who's to say that today I'm not IR but in a few months I could be?
>> >> >Perhaps that is why people who do not officially test positive for
>> >> >IR
>> >> >still reep the benefits and relief that glucophage can provide.
>> >> >I'd
>> >> >rather take that approach then continue gaining weight dispite my
>> >> >efforts with diet and exercise and end up with type II diabetes some
>> >> >day. True, MET is not a hormone, but you can't dismiss the effects
>> >> >it
>> >> >has on hormones even in people without IR. If glucophage seems
>> >> >to help
>> >> >even non-IR people, and relatively safe, then why fight it? Why is
>> >> >it
>> >> >that non-IR people still have high testosterone levels and glucophage
>> >> >helps them? I think they're still working on that one. If there's
>> >> >one
>> >> >thing we *do* know, we don't know everything about this disease.
>> >> >I
>> >> >believe in order to make srtides in an attempt to tackle this disease,
>> >> >we need to be open-minded.
>> >> >Monica
>> >> >At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
>> >> >>
>> >> >>And what are you citing? I was in a University of Michigan Rezulin
>> >> >>study, one of the requirements was Insulin Resistance. Their
>> >> >info
>> >> >>specifically said that only half to 3/4s of the women w/PCOS had IR.
>> >> >And
>> >> >>how can the Met work on anything other than IR? For those of us with
>> >> >it,
>> >> >>it's the IR that causes the testosterone dysfunction. Met's
>> >> >not a
>> >> >>hormone, so I have no idea where you're getting this info.
>> >> >>
>> >> >>At Sat, 29 Jul 2000, Monica wrote:
>> >> >>>
>> >> >>>Stacey,
>> >> >>>I respectfully disagree. The new studies show that MET is effective
>> >> >in
>> >> >>>treating PCOS patients who do not show signs of insulin resistance.
>> >> >PCOS
>> >> >>>manifests itslef in two ways, IR and testosterone/androgen disfunction.
>> >> >>>The MET works on both things. I suggest before making such
>> >> >glib answers
>> >> >>>you check your facts, please.
>> >> >>>Monica
>> >> >>>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
>> >> >>>>
>> >> >>>>But what do you think that Met will do for you? It's sole purpose
>> >> >in
>> >> >>>>being is to fix insulin issues. That's like giving someone
>> >> >with a bad
>> >> >>>>heart a new brain to fix the problem.
>> >> >>>>
>> >> >>>>At Thu, 27 Jul 2000, melissa wrote:
>> >> >>>>>
>> >> >>>>>i'm on glucophage and my doctor never checked my insulin level.
>> >> >We also
>> >> >>>>>fought until he gave in. he just checked my liver and kidneys
>> >> >first.
>> >> >good
>> >> >>>>>luck, melissa
>> >> >>>>>
>> >> >>>>>>From: Goldsngurl@aol.com (Laura)
>> >> >>>>>>Reply-To: pcos-medication@obgyn.net
>> >> >>>>>>To: Multiple recipients of list PCOS-MEDICATION
>> >> >>>>>><pcos-medication@mail.medispecialty.com>
>> >> >>>>>>Subject: Metformin anyone?
>> >> >>>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
>> >> >>>>>>
>> >> >>>>>>Hey! Is anyone currently on Metformin and not insulin resistant?
>> >> >I am
>> >> >>>>>>currently head to head with my doctor, but she won't budge.
>> >> >Pls let me
>> >> >>>>>>know!
>> >> >>>>>>
>> >> >>>>>>--
>> >> >>>>>>Thanks!
>> >> >>>>>>Laura
>> >> >>>>>>
>> >> >
>> >> >--------------2D87DD81E9879D793D00B135--
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>> --
>> Thanks!
>> Laura
>>
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--
Laura
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