Re: Amy, Clara, Monica,Re: Metformin anyone?
From: Amy (anonymous@obgyn.net)
Wed, 02 Aug 2000 08:15:27 -0400
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Hi there Laura - I wish you the best of luck!!! (: Amy
Laura wrote:
> You all have given me hope again...thank you! I am going to my doctor on
> the 8th and TELLING her to try me on Metformin. Are any of you in
> Michigan? I desperately need to find an intelligent PCOS doctor here.
>
> At Mon, 31 Jul 2000, Amy wrote:
> >
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> >Hi Monica - I tolerate it okay... I am on 1000 mg per day where as I think most are on
> >1500 mg per day ... at first I had horrible upset stomachs but now it is on and off -
> >minimum 2 times a week.
> >I can tell a difference as far as Met in comb with levlite (bcp) ... I am in such
> >better emotional health ... I still have a pain occasionally in my lower abdomen (cysts
> >I guess) but not like I had.
> >I came to a stand still with weight loss so I am now on Xenical also ... have lost 12
> >lbs on top of the 8 that I lost while on met/bcp alone. It took me 4 weeks to not have
> >such horrible stomach upsets ... I do feel better emotionaly and physically as far not
> >having horrible cramps all the time - also - I was having bouts of hypoglycemia
> >frequently ...
> >My bloodwork is to be monitored every 3 months as I have endometreosis, diabetes and
> >heart disease in my immediate family ... give it a while .... I do feel so much better
> >...
> >Best of Luck to you!!!!! (: Amy
> >Monica wrote:
> >
> >> So very interesting. It makes sense to me about Met keeping everything
> >> even keel and how that might be the reason it works for nonIR PCOSers. I
> >> would love to learn more about this. Amy, how have you been tolerating
> >> the MET? My doc (a GP at my HMO) put me on MET without testing for IR.
> >> Based upon my high testosterone, high DHEAS, obvious outward signs of
> >> apple shape, hirsutism, and family history of diabetes, as well as
> >> medical journal articles about PCOS that HE read, he felt MET would work
> >> for me. So I may be IR or I may not be. At first I really wanted to
> >> know but then I realized it wouldn't change anything and I didn't want
> >> waste any more time. At least he wanted to give it a try for which I am
> >> grateful. He also stressed the importance of regular exercise and a
> >> diet filled with adequate amounts of protein, fat, and whole grains,
> >> fruits, and veggies. So I may be IR or I may not be. At first I really
> >> wanted to know but then I realized it wouldn't change my course of
> >> action and I didn't want to waste any more time before beginning
> >> treatment. I've been on MET for 6 DAYS now and so far nothing terrible
> >> in terms of side effects, (a little cramping and gas the first few days,
> >> and a little nausea that comes and goes in waves). I'm going to give it
> >> at least six months. Then I'll reevaluate things.
> >> Ooops, sorry to blather on so long! I'd love to hear how you are doing.
> >> :)Monica
> >>
> >> At Mon, 31 Jul 2000, Amy wrote:
> >> >
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> >> >
> >> >--------------2D87DD81E9879D793D00B135
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> >> >
> >> >Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant ... From
> >> >what my Doctor told me, Met helps to keep from becoming completely IR .... From
> >> >what I have read in journals, also, is that PCOS is actually caused from Insulin
> >> >ups and downs, not PCOS causing IR .... I have been on Met for about 3 months now
> >> >without being IR ...so I also respectfully disagree.... The point of Met is to
> >> >help "even Keel" everything to avoid hyper and hypoinsulinism. Hope everyone has
> >> >a wonderful day!!! (: Amy
> >> >
> >> >"Avalos, Clara" wrote:
> >> >
> >> >> Monica...
> >> >>
> >> >> It's Monday morning and I am racing through posts from the weekend... been
> >> >> following this thread with interest, though... I just wanted to send over
> >> >> some support for your assertions... From all the reading that I have been
> >> >> doing, I've come to pretty much the same conclusions that you write here in
> >> >> your message below. Thanks for putting it so well!
> >> >>
> >> >> =o) Hugs,
> >> >>
> >> >> Clara
> >> >>
> >> >> -----Original Message-----
> >> >> From: anonymous@obgyn.net [mailto:anonymous@obgyn.net]
> >> >> Sent: Sunday, July 30, 2000 8:48 AM
> >> >> To: Multiple recipients of list PCOS-MEDICATION
> >> >> Subject: Re: Metformin anyone?
> >> >>
> >> >> You are entitled to your opinion. I'm basing my opinion on previous
> >> >> posts from this forum's archives, journal articles I've read and the
> >> >> following taken from "PCOS Frequently Asked Questions" at
> >> >> http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
> >> >> Information Dissemination):"... At least 30% of women with PCOS are
> >> >> insulin resistant, although some investigators claim a much stronger
> >> >> association exists. ...It appears that even some patients who so not
> >> >> test as being insulin resistant may benefit from these medication. Some
> >> >> doctors do give insulin-sensitizing medications to patients with PCOS,
> >> >> including lean women, whether or not they test as clearly being insulin
> >> >> resistant. Though studies are needed to firmly establish the benefit,
> >> >> many patients appear to experience improvements in symptoms and cycling.
> >> >> The cause of this improvement is unclear." Whether one is diagnosed as
> >> >> IR seems to be a mute point. We know this is a progressive disease,
> >> >> who's to say that today I'm not IR but in a few months I could be?
> >> >> Perhaps that is why people who do not officially test positive for IR
> >> >> still reep the benefits and relief that glucophage can provide. I'd
> >> >> rather take that approach then continue gaining weight dispite my
> >> >> efforts with diet and exercise and end up with type II diabetes some
> >> >> day. True, MET is not a hormone, but you can't dismiss the effects it
> >> >> has on hormones even in people without IR. If glucophage seems to help
> >> >> even non-IR people, and relatively safe, then why fight it? Why is it
> >> >> that non-IR people still have high testosterone levels and glucophage
> >> >> helps them? I think they're still working on that one. If there's one
> >> >> thing we *do* know, we don't know everything about this disease. I
> >> >> believe in order to make srtides in an attempt to tackle this disease,
> >> >> we need to be open-minded.
> >> >> Monica
> >> >>
> >> >> At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
> >> >> >
> >> >> >And what are you citing? I was in a University of Michigan Rezulin
> >> >> >study, one of the requirements was Insulin Resistance. Their info
> >> >> >specifically said that only half to 3/4s of the women w/PCOS had IR. And
> >> >> >how can the Met work on anything other than IR? For those of us with it,
> >> >> >it's the IR that causes the testosterone dysfunction. Met's not a
> >> >> >hormone, so I have no idea where you're getting this info.
> >> >> >
> >> >> >At Sat, 29 Jul 2000, Monica wrote:
> >> >> >>
> >> >> >>Stacey,
> >> >> >>I respectfully disagree. The new studies show that MET is effective in
> >> >> >>treating PCOS patients who do not show signs of insulin resistance. PCOS
> >> >> >>manifests itslef in two ways, IR and testosterone/androgen disfunction.
> >> >> >>The MET works on both things. I suggest before making such glib answers
> >> >> >>you check your facts, please.
> >> >> >>Monica
> >> >> >>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
> >> >> >>>
> >> >> >>>But what do you think that Met will do for you? It's sole purpose in
> >> >> >>>being is to fix insulin issues. That's like giving someone with a bad
> >> >> >>>heart a new brain to fix the problem.
> >> >> >>>
> >> >> >>>At Thu, 27 Jul 2000, melissa wrote:
> >> >> >>>>
> >> >> >>>>i'm on glucophage and my doctor never checked my insulin level. We also
> >> >> >>>>fought until he gave in. he just checked my liver and kidneys first.
> >> >> good
> >> >> >>>>luck, melissa
> >> >> >>>>
> >> >> >>>>>From: Goldsngurl@aol.com (Laura)
> >> >> >>>>>Reply-To: pcos-medication@obgyn.net
> >> >> >>>>>To: Multiple recipients of list PCOS-MEDICATION
> >> >> >>>>><pcos-medication@mail.medispecialty.com>
> >> >> >>>>>Subject: Metformin anyone?
> >> >> >>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
> >> >> >>>>>
> >> >> >>>>>Hey! Is anyone currently on Metformin and not insulin resistant? I am
> >> >> >>>>>currently head to head with my doctor, but she won't budge. Pls let me
> >> >> >>>>>know!
> >> >> >>>>>
> >> >> >>>>>--
> >> >> >>>>>Thanks!
> >> >> >>>>>Laura
> >> >> >>>>>
> >> >>
> >> >--------------2D87DD81E9879D793D00B135
> >> >Content-Type: text/html; charset=us-ascii
> >> >Content-Transfer-Encoding: 7bit
> >> >
> >> ><!doctype html public "-//w3c//dtd html 4.0 transitional//en">
> >> >
> >> >Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant
> >> >.. From what my Doctor told me, Met helps to keep from becoming completely
> >> >IR .... From what I have read in journals, also, is that PCOS is actually
> >> >caused from Insulin ups and downs, not PCOS causing IR .... I have been
> >> >on Met for about 3 months now without being IR ...so I also respectfully
> >> >disagree.... The point of Met is to help "even Keel" everything to
> >> >avoid hyper and hypoinsulinism. Hope everyone has a wonderful day!!!
> >> >(: Amy
> >> >"Avalos, Clara" wrote:
> >> >Monica...
> >> >It's Monday morning and I am racing through posts from the weekend...
> >> >been
> >> >following this thread with interest, though... I just wanted to send
> >> >over
> >> >some support for your assertions... From all the reading that I have
> >> >been
> >> >doing, I've come to pretty much the same conclusions that you write
> >> >here in
> >> >your message below. Thanks for putting it so well!
> >> >=o) Hugs,
> >> >Clara
> >> >-----Original Message-----
> >> >From: anonymous@obgyn.net [mailto:anonymous@obgyn.net]
> >> >Sent: Sunday, July 30, 2000 8:48 AM
> >> >To: Multiple recipients of list PCOS-MEDICATION
> >> >Subject: Re: Metformin anyone?
> >> >You are entitled to your opinion. I'm basing my opinion on previous
> >> >posts from this forum's archives, journal articles I've read and the
> >> >following taken from "PCOS Frequently Asked Questions" at
> >> >http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
> >> >Information Dissemination):"... At least 30% of women with PCOS
> >> >are
> >> >insulin resistant, although some investigators claim a much stronger
> >> >association exists. ...It appears that even some patients who
> >> >so not
> >> >test as being insulin resistant may benefit from these medication.
> >> >Some
> >> >doctors do give insulin-sensitizing medications to patients with PCOS,
> >> >including lean women, whether or not they test as clearly being insulin
> >> >resistant. Though studies are needed to firmly establish the
> >> >benefit,
> >> >many patients appear to experience improvements in symptoms and cycling.
> >> >The cause of this improvement is unclear." Whether one is diagnosed
> >> >as
> >> >IR seems to be a mute point. We know this is a progressive disease,
> >> >who's to say that today I'm not IR but in a few months I could be?
> >> >Perhaps that is why people who do not officially test positive for
> >> >IR
> >> >still reep the benefits and relief that glucophage can provide.
> >> >I'd
> >> >rather take that approach then continue gaining weight dispite my
> >> >efforts with diet and exercise and end up with type II diabetes some
> >> >day. True, MET is not a hormone, but you can't dismiss the effects
> >> >it
> >> >has on hormones even in people without IR. If glucophage seems
> >> >to help
> >> >even non-IR people, and relatively safe, then why fight it? Why is
> >> >it
> >> >that non-IR people still have high testosterone levels and glucophage
> >> >helps them? I think they're still working on that one. If there's
> >> >one
> >> >thing we *do* know, we don't know everything about this disease.
> >> >I
> >> >believe in order to make srtides in an attempt to tackle this disease,
> >> >we need to be open-minded.
> >> >Monica
> >> >At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
> >> >>
> >> >>And what are you citing? I was in a University of Michigan Rezulin
> >> >>study, one of the requirements was Insulin Resistance. Their
> >> >info
> >> >>specifically said that only half to 3/4s of the women w/PCOS had IR.
> >> >And
> >> >>how can the Met work on anything other than IR? For those of us with
> >> >it,
> >> >>it's the IR that causes the testosterone dysfunction. Met's
> >> >not a
> >> >>hormone, so I have no idea where you're getting this info.
> >> >>
> >> >>At Sat, 29 Jul 2000, Monica wrote:
> >> >>>
> >> >>>Stacey,
> >> >>>I respectfully disagree. The new studies show that MET is effective
> >> >in
> >> >>>treating PCOS patients who do not show signs of insulin resistance.
> >> >PCOS
> >> >>>manifests itslef in two ways, IR and testosterone/androgen disfunction.
> >> >>>The MET works on both things. I suggest before making such
> >> >glib answers
> >> >>>you check your facts, please.
> >> >>>Monica
> >> >>>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
> >> >>>>
> >> >>>>But what do you think that Met will do for you? It's sole purpose
> >> >in
> >> >>>>being is to fix insulin issues. That's like giving someone
> >> >with a bad
> >> >>>>heart a new brain to fix the problem.
> >> >>>>
> >> >>>>At Thu, 27 Jul 2000, melissa wrote:
> >> >>>>>
> >> >>>>>i'm on glucophage and my doctor never checked my insulin level.
> >> >We also
> >> >>>>>fought until he gave in. he just checked my liver and kidneys
> >> >first.
> >> >good
> >> >>>>>luck, melissa
> >> >>>>>
> >> >>>>>>From: Goldsngurl@aol.com (Laura)
> >> >>>>>>Reply-To: pcos-medication@obgyn.net
> >> >>>>>>To: Multiple recipients of list PCOS-MEDICATION
> >> >>>>>><pcos-medication@mail.medispecialty.com>
> >> >>>>>>Subject: Metformin anyone?
> >> >>>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
> >> >>>>>>
> >> >>>>>>Hey! Is anyone currently on Metformin and not insulin resistant?
> >> >I am
> >> >>>>>>currently head to head with my doctor, but she won't budge.
> >> >Pls let me
> >> >>>>>>know!
> >> >>>>>>
> >> >>>>>>--
> >> >>>>>>Thanks!
> >> >>>>>>Laura
> >> >>>>>>
> >> >
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>
> --
> Thanks!
> Laura
>
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