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Re: Amy, Clara, Monica,Re: Metformin anyone?

From: anonymous@obgyn.net
Tue, 1 Aug 2000 22:19:32 -0500 (CDT)

If you're in SE Michigan, most of the U of Michigan docs are pretty knowledgeable. But like I've said before, they probably won't put you on Met without a positive IR test - they just shut a Rezulin study down a year ago - it required PCOS patients to be IR. (I know, I participated).

At Tue, 1 Aug 2000, Laura wrote: >
>You all have given me hope again...thank you! I am going to my doctor on
>the 8th and TELLING her to try me on Metformin. Are any of you in
>Michigan? I desperately need to find an intelligent PCOS doctor here.
>
>At Mon, 31 Jul 2000, Amy wrote:
>>
>>Content-Type: text/plain; charset=us-ascii
>>Content-Transfer-Encoding: 7bit
>>
>>Hi Monica - I tolerate it okay... I am on 1000 mg per day where as I think most are on
>>1500 mg per day ... at first I had horrible upset stomachs but now it is on and off -
>>minimum 2 times a week.
>>I can tell a difference as far as Met in comb with levlite (bcp) ... I am in such
>>better emotional health ... I still have a pain occasionally in my lower abdomen (cysts
>>I guess) but not like I had.
>>I came to a stand still with weight loss so I am now on Xenical also ... have lost 12
>>lbs on top of the 8 that I lost while on met/bcp alone. It took me 4 weeks to not have
>>such horrible stomach upsets ... I do feel better emotionaly and physically as far not
>>having horrible cramps all the time - also - I was having bouts of hypoglycemia
>>frequently ...
>>My bloodwork is to be monitored every 3 months as I have endometreosis, diabetes and
>>heart disease in my immediate family ... give it a while .... I do feel so much better
>>...
>>Best of Luck to you!!!!! (: Amy
>>Monica wrote:
>>
>>> So very interesting. It makes sense to me about Met keeping everything
>>> even keel and how that might be the reason it works for nonIR PCOSers. I
>>> would love to learn more about this. Amy, how have you been tolerating
>>> the MET? My doc (a GP at my HMO) put me on MET without testing for IR.
>>> Based upon my high testosterone, high DHEAS, obvious outward signs of
>>> apple shape, hirsutism, and family history of diabetes, as well as
>>> medical journal articles about PCOS that HE read, he felt MET would work
>>> for me. So I may be IR or I may not be. At first I really wanted to
>>> know but then I realized it wouldn't change anything and I didn't want
>>> waste any more time. At least he wanted to give it a try for which I am
>>> grateful. He also stressed the importance of regular exercise and a
>>> diet filled with adequate amounts of protein, fat, and whole grains,
>>> fruits, and veggies. So I may be IR or I may not be. At first I really
>>> wanted to know but then I realized it wouldn't change my course of
>>> action and I didn't want to waste any more time before beginning
>>> treatment. I've been on MET for 6 DAYS now and so far nothing terrible
>>> in terms of side effects, (a little cramping and gas the first few days,
>>> and a little nausea that comes and goes in waves). I'm going to give it
>>> at least six months. Then I'll reevaluate things.
>>> Ooops, sorry to blather on so long! I'd love to hear how you are doing.
>>> :)Monica
>>>
>>> At Mon, 31 Jul 2000, Amy wrote:
>>> >
>>> >Content-Type: multipart/alternative;
>>> > boundary="------------2D87DD81E9879D793D00B135"
>>> >
>>> >--------------2D87DD81E9879D793D00B135
>>> >Content-Type: text/plain; charset=us-ascii
>>> >Content-Transfer-Encoding: 7bit
>>> >
>>> >Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant ... From
>>> >what my Doctor told me, Met helps to keep from becoming completely IR .... From
>>> >what I have read in journals, also, is that PCOS is actually caused from Insulin
>>> >ups and downs, not PCOS causing IR .... I have been on Met for about 3 months now
>>> >without being IR ...so I also respectfully disagree.... The point of Met is to
>>> >help "even Keel" everything to avoid hyper and hypoinsulinism. Hope everyone has
>>> >a wonderful day!!! (: Amy
>>> >
>>> >"Avalos, Clara" wrote:
>>> >
>>> >> Monica...
>>> >>
>>> >> It's Monday morning and I am racing through posts from the weekend... been
>>> >> following this thread with interest, though... I just wanted to send over
>>> >> some support for your assertions... From all the reading that I have been
>>> >> doing, I've come to pretty much the same conclusions that you write here in
>>> >> your message below. Thanks for putting it so well!
>>> >>
>>> >> =o) Hugs,
>>> >>
>>> >> Clara
>>> >>
>>> >> -----Original Message-----
>>> >> From: anonymous@obgyn.net [mailto:anonymous@obgyn.net]
>>> >> Sent: Sunday, July 30, 2000 8:48 AM
>>> >> To: Multiple recipients of list PCOS-MEDICATION
>>> >> Subject: Re: Metformin anyone?
>>> >>
>>> >> You are entitled to your opinion. I'm basing my opinion on previous
>>> >> posts from this forum's archives, journal articles I've read and the
>>> >> following taken from "PCOS Frequently Asked Questions" at
>>> >> http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
>>> >> Information Dissemination):"... At least 30% of women with PCOS are
>>> >> insulin resistant, although some investigators claim a much stronger
>>> >> association exists. ...It appears that even some patients who so not
>>> >> test as being insulin resistant may benefit from these medication. Some
>>> >> doctors do give insulin-sensitizing medications to patients with PCOS,
>>> >> including lean women, whether or not they test as clearly being insulin
>>> >> resistant. Though studies are needed to firmly establish the benefit,
>>> >> many patients appear to experience improvements in symptoms and cycling.
>>> >> The cause of this improvement is unclear." Whether one is diagnosed as
>>> >> IR seems to be a mute point. We know this is a progressive disease,
>>> >> who's to say that today I'm not IR but in a few months I could be?
>>> >> Perhaps that is why people who do not officially test positive for IR
>>> >> still reep the benefits and relief that glucophage can provide. I'd
>>> >> rather take that approach then continue gaining weight dispite my
>>> >> efforts with diet and exercise and end up with type II diabetes some
>>> >> day. True, MET is not a hormone, but you can't dismiss the effects it
>>> >> has on hormones even in people without IR. If glucophage seems to help
>>> >> even non-IR people, and relatively safe, then why fight it? Why is it
>>> >> that non-IR people still have high testosterone levels and glucophage
>>> >> helps them? I think they're still working on that one. If there's one
>>> >> thing we *do* know, we don't know everything about this disease. I
>>> >> believe in order to make srtides in an attempt to tackle this disease,
>>> >> we need to be open-minded.
>>> >> Monica
>>> >>
>>> >> At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
>>> >> >
>>> >> >And what are you citing? I was in a University of Michigan Rezulin
>>> >> >study, one of the requirements was Insulin Resistance. Their info
>>> >> >specifically said that only half to 3/4s of the women w/PCOS had IR. And
>>> >> >how can the Met work on anything other than IR? For those of us with it,
>>> >> >it's the IR that causes the testosterone dysfunction. Met's not a
>>> >> >hormone, so I have no idea where you're getting this info.
>>> >> >
>>> >> >At Sat, 29 Jul 2000, Monica wrote:
>>> >> >>
>>> >> >>Stacey,
>>> >> >>I respectfully disagree. The new studies show that MET is effective in
>>> >> >>treating PCOS patients who do not show signs of insulin resistance. PCOS
>>> >> >>manifests itslef in two ways, IR and testosterone/androgen disfunction.
>>> >> >>The MET works on both things. I suggest before making such glib answers
>>> >> >>you check your facts, please.
>>> >> >>Monica
>>> >> >>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
>>> >> >>>
>>> >> >>>But what do you think that Met will do for you? It's sole purpose in
>>> >> >>>being is to fix insulin issues. That's like giving someone with a bad
>>> >> >>>heart a new brain to fix the problem.
>>> >> >>>
>>> >> >>>At Thu, 27 Jul 2000, melissa wrote:
>>> >> >>>>
>>> >> >>>>i'm on glucophage and my doctor never checked my insulin level. We also
>>> >> >>>>fought until he gave in. he just checked my liver and kidneys first.
>>> >> good
>>> >> >>>>luck, melissa
>>> >> >>>>
>>> >> >>>>>From: Goldsngurl@aol.com (Laura)
>>> >> >>>>>Reply-To: pcos-medication@obgyn.net
>>> >> >>>>>To: Multiple recipients of list PCOS-MEDICATION
>>> >> >>>>><pcos-medication@mail.medispecialty.com>
>>> >> >>>>>Subject: Metformin anyone?
>>> >> >>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
>>> >> >>>>>
>>> >> >>>>>Hey! Is anyone currently on Metformin and not insulin resistant? I am
>>> >> >>>>>currently head to head with my doctor, but she won't budge. Pls let me
>>> >> >>>>>know!
>>> >> >>>>>
>>> >> >>>>>--
>>> >> >>>>>Thanks!
>>> >> >>>>>Laura
>>> >> >>>>>
>>> >>
>>> >--------------2D87DD81E9879D793D00B135
>>> >Content-Type: text/html; charset=us-ascii
>>> >Content-Transfer-Encoding: 7bit
>>> >
>>> ><!doctype html public "-//w3c//dtd html 4.0 transitional//en">
>>> >
>>> >Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant
>>> >.. From what my Doctor told me, Met helps to keep from becoming completely
>>> >IR .... From what I have read in journals, also, is that PCOS is actually
>>> >caused from Insulin ups and downs, not PCOS causing IR .... I have been
>>> >on Met for about 3 months now without being IR ...so I also respectfully
>>> >disagree.... The point of Met is to help "even Keel" everything to
>>> >avoid hyper and hypoinsulinism. Hope everyone has a wonderful day!!!
>>> >(: Amy
>>> >"Avalos, Clara" wrote:
>>> >Monica...
>>> >It's Monday morning and I am racing through posts from the weekend...
>>> >been
>>> >following this thread with interest, though... I just wanted to send
>>> >over
>>> >some support for your assertions... From all the reading that I have
>>> >been
>>> >doing, I've come to pretty much the same conclusions that you write
>>> >here in
>>> >your message below. Thanks for putting it so well!
>>> >=o) Hugs,
>>> >Clara
>>> >-----Original Message-----
>>> >From: anonymous@obgyn.net [mailto:anonymous@obgyn.net]
>>> >Sent: Sunday, July 30, 2000 8:48 AM
>>> >To: Multiple recipients of list PCOS-MEDICATION
>>> >Subject: Re: Metformin anyone?
>>> >You are entitled to your opinion. I'm basing my opinion on previous
>>> >posts from this forum's archives, journal articles I've read and the
>>> >following taken from "PCOS Frequently Asked Questions" at
>>> >http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
>>> >Information Dissemination):"... At least 30% of women with PCOS
>>> >are
>>> >insulin resistant, although some investigators claim a much stronger
>>> >association exists. ...It appears that even some patients who
>>> >so not
>>> >test as being insulin resistant may benefit from these medication.
>>> >Some
>>> >doctors do give insulin-sensitizing medications to patients with PCOS,
>>> >including lean women, whether or not they test as clearly being insulin
>>> >resistant. Though studies are needed to firmly establish the
>>> >benefit,
>>> >many patients appear to experience improvements in symptoms and cycling.
>>> >The cause of this improvement is unclear." Whether one is diagnosed
>>> >as
>>> >IR seems to be a mute point. We know this is a progressive disease,
>>> >who's to say that today I'm not IR but in a few months I could be?
>>> >Perhaps that is why people who do not officially test positive for
>>> >IR
>>> >still reep the benefits and relief that glucophage can provide.
>>> >I'd
>>> >rather take that approach then continue gaining weight dispite my
>>> >efforts with diet and exercise and end up with type II diabetes some
>>> >day. True, MET is not a hormone, but you can't dismiss the effects
>>> >it
>>> >has on hormones even in people without IR. If glucophage seems
>>> >to help
>>> >even non-IR people, and relatively safe, then why fight it? Why is
>>> >it
>>> >that non-IR people still have high testosterone levels and glucophage
>>> >helps them? I think they're still working on that one. If there's
>>> >one
>>> >thing we *do* know, we don't know everything about this disease.
>>> >I
>>> >believe in order to make srtides in an attempt to tackle this disease,
>>> >we need to be open-minded.
>>> >Monica
>>> >At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
>>> >>
>>> >>And what are you citing? I was in a University of Michigan Rezulin
>>> >>study, one of the requirements was Insulin Resistance. Their
>>> >info
>>> >>specifically said that only half to 3/4s of the women w/PCOS had IR.
>>> >And
>>> >>how can the Met work on anything other than IR? For those of us with
>>> >it,
>>> >>it's the IR that causes the testosterone dysfunction. Met's
>>> >not a
>>> >>hormone, so I have no idea where you're getting this info.
>>> >>
>>> >>At Sat, 29 Jul 2000, Monica wrote:
>>> >>>
>>> >>>Stacey,
>>> >>>I respectfully disagree. The new studies show that MET is effective
>>> >in
>>> >>>treating PCOS patients who do not show signs of insulin resistance.
>>> >PCOS
>>> >>>manifests itslef in two ways, IR and testosterone/androgen disfunction.
>>> >>>The MET works on both things. I suggest before making such
>>> >glib answers
>>> >>>you check your facts, please.
>>> >>>Monica
>>> >>>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
>>> >>>>
>>> >>>>But what do you think that Met will do for you? It's sole purpose
>>> >in
>>> >>>>being is to fix insulin issues. That's like giving someone
>>> >with a bad
>>> >>>>heart a new brain to fix the problem.
>>> >>>>
>>> >>>>At Thu, 27 Jul 2000, melissa wrote:
>>> >>>>>
>>> >>>>>i'm on glucophage and my doctor never checked my insulin level.
>>> >We also
>>> >>>>>fought until he gave in. he just checked my liver and kidneys
>>> >first.
>>> >good
>>> >>>>>luck, melissa
>>> >>>>>
>>> >>>>>>From: Goldsngurl@aol.com (Laura)
>>> >>>>>>Reply-To: pcos-medication@obgyn.net
>>> >>>>>>To: Multiple recipients of list PCOS-MEDICATION
>>> >>>>>><pcos-medication@mail.medispecialty.com>
>>> >>>>>>Subject: Metformin anyone?
>>> >>>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
>>> >>>>>>
>>> >>>>>>Hey! Is anyone currently on Metformin and not insulin resistant?
>>> >I am
>>> >>>>>>currently head to head with my doctor, but she won't budge.
>>> >Pls let me
>>> >>>>>>know!
>>> >>>>>>
>>> >>>>>>--
>>> >>>>>>Thanks!
>>> >>>>>>Laura
>>> >>>>>>
>>> >
>>> >--------------2D87DD81E9879D793D00B135--
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>>> >Content-Description: Card for Amy Crowe - Pricing Analyst
>>> >Content-Disposition: attachment;
>>> > filename="amy.crowe.vcf"
>>> >
>>> >begin:vcard
>>> >n:Crowe;Amy
>>> >tel;fax:770-795-4794
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>>> >org:TRISM, Inc.;Pricing Department
>>> >version:2.1
>>> >email;internet:amy.crowe@trism.com
>>> >title:Pricing Analyst - Commercial
>>> >adr;quoted-printable:;;4174 Jiles Road
>>> P.O. Box 9000;Kennesaw;GA;30144;USA
>>> >fn:Amy R. Crowe
>>> >end:vcard
>>> >
>>> >--------------BF42469A55A28E4F105B5E66--
>>>
>>--------------3D3ACF30B9AD648F74F5D520
>>Content-Type: text/x-vcard; charset=us-ascii;
>> name="amy.crowe.vcf"
>>Content-Transfer-Encoding: 7bit
>>Content-Description: Card for Amy Crowe - Pricing Analyst
>>Content-Disposition: attachment;
>> filename="amy.crowe.vcf"
>>
>>begin:vcard
>>n:Crowe;Amy
>>tel;fax:770-795-4794
>>tel;work:770-795-4751
>>x-mozilla-html:FALSE
>>url:http://www.trism.com
>>org:TRISM, Inc.;Pricing Department
>>version:2.1
>>email;internet:amy.crowe@trism.com
>>title:Pricing Analyst - Commercial
>>adr;quoted-printable:;;4174 Jiles Road
>P.O. Box 9000;Kennesaw;GA;30144;USA
>>fn:Amy R. Crowe
>>end:vcard
>>
>>--------------3D3ACF30B9AD648F74F5D520--
>
>--
>Thanks!
>Laura
>

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