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Amy, Clara,Re: Metformin anyone?
From: Monica (anonymous@obgyn.net)
Mon, 31 Jul 2000 11:21:50 -0500 (CDT)
So very interesting. It makes sense to me about Met keeping everything
even keel and how that might be the reason it works for nonIR PCOSers. I
would love to learn more about this. Amy, how have you been tolerating
the MET? My doc (a GP at my HMO) put me on MET without testing for IR.
Based upon my high testosterone, high DHEAS, obvious outward signs of
apple shape, hirsutism, and family history of diabetes, as well as
medical journal articles about PCOS that HE read, he felt MET would work
for me. So I may be IR or I may not be. At first I really wanted to
know but then I realized it wouldn't change anything and I didn't want
waste any more time. At least he wanted to give it a try for which I am
grateful. He also stressed the importance of regular exercise and a
diet filled with adequate amounts of protein, fat, and whole grains,
fruits, and veggies. So I may be IR or I may not be. At first I really
wanted to know but then I realized it wouldn't change my course of
action and I didn't want to waste any more time before beginning
treatment. I've been on MET for 6 DAYS now and so far nothing terrible
in terms of side effects, (a little cramping and gas the first few days,
and a little nausea that comes and goes in waves). I'm going to give it
at least six months. Then I'll reevaluate things.
Ooops, sorry to blather on so long! I'd love to hear how you are doing.
:)Monica
At Mon, 31 Jul 2000, Amy wrote:
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>Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant ... From
>what my Doctor told me, Met helps to keep from becoming completely IR .... From
>what I have read in journals, also, is that PCOS is actually caused from Insulin
>ups and downs, not PCOS causing IR .... I have been on Met for about 3 months now
>without being IR ...so I also respectfully disagree.... The point of Met is to
>help "even Keel" everything to avoid hyper and hypoinsulinism. Hope everyone has
>a wonderful day!!! (: Amy
>
>"Avalos, Clara" wrote:
>
>> Monica...
>>
>> It's Monday morning and I am racing through posts from the weekend... been
>> following this thread with interest, though... I just wanted to send over
>> some support for your assertions... From all the reading that I have been
>> doing, I've come to pretty much the same conclusions that you write here in
>> your message below. Thanks for putting it so well!
>>
>> =o) Hugs,
>>
>> Clara
>>
>> -----Original Message-----
>> From: anonymous@obgyn.net [mailto:anonymous@obgyn.net]
>> Sent: Sunday, July 30, 2000 8:48 AM
>> To: Multiple recipients of list PCOS-MEDICATION
>> Subject: Re: Metformin anyone?
>>
>> You are entitled to your opinion. I'm basing my opinion on previous
>> posts from this forum's archives, journal articles I've read and the
>> following taken from "PCOS Frequently Asked Questions" at
>> http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
>> Information Dissemination):"... At least 30% of women with PCOS are
>> insulin resistant, although some investigators claim a much stronger
>> association exists. ...It appears that even some patients who so not
>> test as being insulin resistant may benefit from these medication. Some
>> doctors do give insulin-sensitizing medications to patients with PCOS,
>> including lean women, whether or not they test as clearly being insulin
>> resistant. Though studies are needed to firmly establish the benefit,
>> many patients appear to experience improvements in symptoms and cycling.
>> The cause of this improvement is unclear." Whether one is diagnosed as
>> IR seems to be a mute point. We know this is a progressive disease,
>> who's to say that today I'm not IR but in a few months I could be?
>> Perhaps that is why people who do not officially test positive for IR
>> still reep the benefits and relief that glucophage can provide. I'd
>> rather take that approach then continue gaining weight dispite my
>> efforts with diet and exercise and end up with type II diabetes some
>> day. True, MET is not a hormone, but you can't dismiss the effects it
>> has on hormones even in people without IR. If glucophage seems to help
>> even non-IR people, and relatively safe, then why fight it? Why is it
>> that non-IR people still have high testosterone levels and glucophage
>> helps them? I think they're still working on that one. If there's one
>> thing we *do* know, we don't know everything about this disease. I
>> believe in order to make srtides in an attempt to tackle this disease,
>> we need to be open-minded.
>> Monica
>>
>> At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
>> >
>> >And what are you citing? I was in a University of Michigan Rezulin
>> >study, one of the requirements was Insulin Resistance. Their info
>> >specifically said that only half to 3/4s of the women w/PCOS had IR. And
>> >how can the Met work on anything other than IR? For those of us with it,
>> >it's the IR that causes the testosterone dysfunction. Met's not a
>> >hormone, so I have no idea where you're getting this info.
>> >
>> >At Sat, 29 Jul 2000, Monica wrote:
>> >>
>> >>Stacey,
>> >>I respectfully disagree. The new studies show that MET is effective in
>> >>treating PCOS patients who do not show signs of insulin resistance. PCOS
>> >>manifests itslef in two ways, IR and testosterone/androgen disfunction.
>> >>The MET works on both things. I suggest before making such glib answers
>> >>you check your facts, please.
>> >>Monica
>> >>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
>> >>>
>> >>>But what do you think that Met will do for you? It's sole purpose in
>> >>>being is to fix insulin issues. That's like giving someone with a bad
>> >>>heart a new brain to fix the problem.
>> >>>
>> >>>At Thu, 27 Jul 2000, melissa wrote:
>> >>>>
>> >>>>i'm on glucophage and my doctor never checked my insulin level. We also
>> >>>>fought until he gave in. he just checked my liver and kidneys first.
>> good
>> >>>>luck, melissa
>> >>>>
>> >>>>>From: Goldsngurl@aol.com (Laura)
>> >>>>>Reply-To: pcos-medication@obgyn.net
>> >>>>>To: Multiple recipients of list PCOS-MEDICATION
>> >>>>><pcos-medication@mail.medispecialty.com>
>> >>>>>Subject: Metformin anyone?
>> >>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
>> >>>>>
>> >>>>>Hey! Is anyone currently on Metformin and not insulin resistant? I am
>> >>>>>currently head to head with my doctor, but she won't budge. Pls let me
>> >>>>>know!
>> >>>>>
>> >>>>>--
>> >>>>>Thanks!
>> >>>>>Laura
>> >>>>>
>>
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>Well - to throw my 2 cents in - I am on Met and am not Insuline Resistant
>.. From what my Doctor told me, Met helps to keep from becoming completely
>IR .... From what I have read in journals, also, is that PCOS is actually
>caused from Insulin ups and downs, not PCOS causing IR .... I have been
>on Met for about 3 months now without being IR ...so I also respectfully
>disagree.... The point of Met is to help "even Keel" everything to
>avoid hyper and hypoinsulinism. Hope everyone has a wonderful day!!!
>(: Amy
>"Avalos, Clara" wrote:
>Monica...
>It's Monday morning and I am racing through posts from the weekend...
>been
>following this thread with interest, though... I just wanted to send
>over
>some support for your assertions... From all the reading that I have
>been
>doing, I've come to pretty much the same conclusions that you write
>here in
>your message below. Thanks for putting it so well!
>=o) Hugs,
>Clara
>-----Original Message-----
>From: anonymous@obgyn.net [mailto:anonymous@obgyn.net
>Sent: Sunday, July 30, 2000 8:48 AM
>To: Multiple recipients of list PCOS-MEDICATION
>Subject: Re: Metformin anyone?
>You are entitled to your opinion. I'm basing my opinion on previous
>posts from this forum's archives, journal articles I've read and the
>following taken from "PCOS Frequently Asked Questions" at
>http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility
>Information Dissemination):"... At least 30% of women with PCOS
>are
>insulin resistant, although some investigators claim a much stronger
>association exists. ...It appears that even some patients who
>so not
>test as being insulin resistant may benefit from these medication.
>Some
>doctors do give insulin-sensitizing medications to patients with PCOS,
>including lean women, whether or not they test as clearly being insulin
>resistant. Though studies are needed to firmly establish the
>benefit,
>many patients appear to experience improvements in symptoms and cycling.
>The cause of this improvement is unclear." Whether one is diagnosed
>as
>IR seems to be a mute point. We know this is a progressive disease,
>who's to say that today I'm not IR but in a few months I could be?
>Perhaps that is why people who do not officially test positive for
>IR
>still reep the benefits and relief that glucophage can provide.
>I'd
>rather take that approach then continue gaining weight dispite my
>efforts with diet and exercise and end up with type II diabetes some
>day. True, MET is not a hormone, but you can't dismiss the effects
>it
>has on hormones even in people without IR. If glucophage seems
>to help
>even non-IR people, and relatively safe, then why fight it? Why is
>it
>that non-IR people still have high testosterone levels and glucophage
>helps them? I think they're still working on that one. If there's
>one
>thing we *do* know, we don't know everything about this disease.
>I
>believe in order to make srtides in an attempt to tackle this disease,
>we need to be open-minded.
>Monica
>At Sat, 29 Jul 2000, anonymous@obgyn.net wrote:
>>
>>And what are you citing? I was in a University of Michigan Rezulin
>>study, one of the requirements was Insulin Resistance. Their
>info
>>specifically said that only half to 3/4s of the women w/PCOS had IR.
>And
>>how can the Met work on anything other than IR? For those of us with
>it,
>>it's the IR that causes the testosterone dysfunction. Met's
>not a
>>hormone, so I have no idea where you're getting this info.
>>
>>At Sat, 29 Jul 2000, Monica wrote:
>>>
>>>Stacey,
>>>I respectfully disagree. The new studies show that MET is effective
>in
>>>treating PCOS patients who do not show signs of insulin resistance.
>PCOS
>>>manifests itslef in two ways, IR and testosterone/androgen disfunction.
>>>The MET works on both things. I suggest before making such
>glib answers
>>>you check your facts, please.
>>>Monica
>>>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
>>>>
>>>>But what do you think that Met will do for you? It's sole purpose
>in
>>>>being is to fix insulin issues. That's like giving someone
>with a bad
>>>>heart a new brain to fix the problem.
>>>>
>>>>At Thu, 27 Jul 2000, melissa wrote:
>>>>>
>>>>>i'm on glucophage and my doctor never checked my insulin level.
>We also
>>>>>fought until he gave in. he just checked my liver and kidneys
>first.
>good
>>>>>luck, melissa
>>>>>
>>>>>>From: anonymous@obgyn.net (Laura)
>>>>>>Reply-To: anonymous@obgyn.net
>>>>>>To: Multiple recipients of list PCOS-MEDICATION
>>>>>><pcos-medication@mail.medispecialty.com>
>>>>>>Subject: Metformin anyone?
>>>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
>>>>>>
>>>>>>Hey! Is anyone currently on Metformin and not insulin resistant?
>I am
>>>>>>currently head to head with my doctor, but she won't budge.
>Pls let me
>>>>>>know!
>>>>>>
>>>>>>--
>>>>>>Thanks!
>>>>>>Laura
>>>>>>
>
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