PCOS-MEDICATION Messages for July, 2000: Re: Metformin anyone?

Re: Metformin anyone?

From: Monica (anonymous@obgyn.net)
Sun, 30 Jul 2000 07:45:50 -0500 (CDT)

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You are entitled to your opinion. I'm basing my opinion on previous posts from this forum's archives, journal articles I've read and the following taken from "PCOS Frequently Asked Questions" at http://www.inciid.org/faq/pcos4.html (InterNational Council on Infertility Information Dissemination):"... At least 30% of women with PCOS are insulin resistant, although some investigators claim a much stronger association exists. ...It appears that even some patients who so not test as being insulin resistant may benefit from these medication. Some doctors do give insulin-sensitizing medications to patients with PCOS, including lean women, whether or not they test as clearly being insulin resistant. Though studies are needed to firmly establish the benefit, many patients appear to experience improvements in symptoms and cycling. The cause of this improvement is unclear." Whether one is diagnosed as IR seems to be a mute point. We know this is a progressive disease, who's to say that today I'm not IR but in a few months I could be? Perhaps that is why people who do not officially test positive for IR still reep the benefits and relief that glucophage can provide. I'd rather take that approach then continue gaining weight dispite my efforts with diet and exercise and end up with type II diabetes some day. True, MET is not a hormone, but you can't dismiss the effects it has on hormones even in people without IR. If glucophage seems to help even non-IR people, and relatively safe, then why fight it? Why is it that non-IR people still have high testosterone levels and glucophage helps them? I think they're still working on that one. If there's one thing we *do* know, we don't know everything about this disease. I believe in order to make srtides in an attempt to tackle this disease, we need to be open-minded. Monica

At Sat, 29 Jul 2000, anonymous@obgyn.net wrote: >
>And what are you citing? I was in a University of Michigan Rezulin
>study, one of the requirements was Insulin Resistance. Their info
>specifically said that only half to 3/4s of the women w/PCOS had IR. And
>how can the Met work on anything other than IR? For those of us with it,
>it's the IR that causes the testosterone dysfunction. Met's not a
>hormone, so I have no idea where you're getting this info.
>
>At Sat, 29 Jul 2000, Monica wrote:
>>
>>Stacey,
>>I respectfully disagree. The new studies show that MET is effective in
>>treating PCOS patients who do not show signs of insulin resistance. PCOS
>>manifests itslef in two ways, IR and testosterone/androgen disfunction.
>>The MET works on both things. I suggest before making such glib answers
>>you check your facts, please.
>>Monica
>>At Thu, 27 Jul 2000, anonymous@obgyn.net wrote:
>>>
>>>But what do you think that Met will do for you? It's sole purpose in
>>>being is to fix insulin issues. That's like giving someone with a bad
>>>heart a new brain to fix the problem.
>>>
>>>At Thu, 27 Jul 2000, melissa wrote:
>>>>
>>>>i'm on glucophage and my doctor never checked my insulin level. We also
>>>>fought until he gave in. he just checked my liver and kidneys first. good
>>>>luck, melissa
>>>>
>>>>>From: anonymous@obgyn.net (Laura)
>>>>>Reply-To: anonymous@obgyn.net
>>>>>To: Multiple recipients of list PCOS-MEDICATION
>>>>><pcos-medication@mail.medispecialty.com>
>>>>>Subject: Metformin anyone?
>>>>>Date: Thu, 27 Jul 2000 16:56:13 -0500
>>>>>
>>>>>Hey! Is anyone currently on Metformin and not insulin resistant? I am
>>>>>currently head to head with my doctor, but she won't budge. Pls let me
>>>>>know!
>>>>>
>>>>>--
>>>>>Thanks!
>>>>>Laura
>>>>>

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