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Re: Subset of women with PCOS respond to treatment with diabetes
From: Alina (anonymous@obgyn.net)
Thu, 13 Jul 2000 10:33:35 -0500 (CDT)
Thank you for posting this. I will be sure to bring it to my
endocrinologist's attention when I see her next.
At Thu, 13 Jul 2000, Bruce wrote:
>
>Jul 12 - Metformin therapy reduces fasting insulin levels and improves
>clinical symptoms of hyperandrogenism in women with polycystic ovary
>syndrome and hyperinsulinemia, according to study results published in the
>June issue of Fertility and Sterility.
>
>Dr. Antoni J. Duleba, from Yale University School of Medicine, New Haven,
>Connecticut, and colleagues treated 39 patients with polycystic ovary
>syndrome and elevated fasting insulin levels with 12 weeks of oral
>metformin, at a dosage of 500 mg, three times a day. Four women became
>pregnant during treatment and were not included in the final analysis.
>
>By the end of the treatment period, fasting insulin levels had dropped by
>over 30%, while the glucose-to-insulin ratio increased by 33%, the authors
>determined. The group also observed an almost 40% decline in the
>free-testosterone index. Body mass index and the waist-hip ratio dropped
>slightly but significantly.
>
>"Clinical manifestations of hyperandrogenism also improved," the authors
>report, although improvement was influenced by baseline DHEA
>concentrations. Overall, the acne score dropped by 14%; the hirsutism score
>by 2.3%, and the average length of the menstrual cycle by 36%.
>
>Levels of insulin-like growth factor I showed little response to metformin
>treatment in women with normal baseline DHEAS concentrations, but the
>levels increased by 9.5% in women with high baseline DHEAS concentrations.
>
>"It appears that patients with adrenal hyperfunction represent a unique
>subpopulation of polycystic ovary syndrome," the authors write.
>
>Fertil Steril 2000;73:1149-1154.
>
>-Westport Newsroom 203 319 2700
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>
>--
>Bruce Speyer, CTO Home of OBGYN.net
>MediSpecialty.com The Universe of Women's Health
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>EMAIL: anonymous@obgyn.net
>
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