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PCOS Genetic Information Released on MedscapeFrom: PCOSupport (anonymous@obgyn.net)Mon, 26 Jun 2000 11:46:31 -0500
PCOS Gene Localized to Insulin Receptor Gene Region -------------------------------------------------------------------------- By Pippa Wysong -------------------------------------------------------------------------- -------------------------------------------------------------------------- TORONTO, Jun 22 (Reuters Health) - The locus of a gene that may influence susceptibility for polycystic ovary syndrome (PCOS) lies near the insulin gene receptor on chromosome 19, a research team from Mount Sinai School of Medicine, New York, announced at the 82nd annual meeting of the Endocrine Society. "Doing a glucose tolerance test or actually a simple blood sugar can uncover diabetes in about 10% of women who show up at the clinic with PCOS symptoms," said Dr. Yaron Tomer. Because of the high rate of diabetes-type symptoms, mutations in regions near the insulin receptor genes have been suspected in PCOS. A genetic study was done in 172 premenopausal women, half of whom had been diagnosed with classic PCOS symptoms while the others were healthy and had no signs of PCOS. The results identified the insulin receptor gene microsatellite marker D19S884 to be associated with PCOS. "The marker itself is not a mutation, and doesn't cause anything. But we know that near this marker there are several genes that we can now start testing," Dr. Tomer said. The gene, when found, may be one that is directly related to the development of type-2 diabetes mellitus, may somehow interfere with insulin pathways, or may affect a completely different aspect of the disease.
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