Re: Calcium, Vitamin D & PCOS
From: Victoria (anonymous@obgyn.net)
Thu, 19 Sep 2002 8:15:20 -0400
Does it say whether diet or exercise changes were ruled out or how long the effects were for? How about any other problems like hirsutism, how was that effected? I'm wondering if we could get a copy at the local medical library. Was it compared to a placebo?
--
Victoria
> From: anonymous@medispecialty.com (Denise)
> I am new here, so Hi!!
>
> I have read a few interesting things about Calcium and Vit D - see
> below adstract.
>
> Also picked up a mail from this group from someone with an
> email address : anonymous@medispecialty.com, who over a
> year ago help her pcos with calcium and Zinc. Do you, or
> other pco'er have any info.
> Take Care
> Denise
> Vitamin D and calcium dysregulation in the polycystic ovarian syndrome.
>
> Thys-Jacobs S, Donovan D, Papadopoulos A, Sarrel P, Bilezikian JP.
>
> Department of Medicine, St. Lukes-Roosevelt Hospital Center, Columbia
> University, College of Physicians & Surgeons, New York, NY 10019, USA.
>
> Over the past 30 years, numerous studies in invertebrates and
> vertebrates have established a role of calcium in oocyte maturation as
> well as in the resumption and progression of follicular development.
> Polycystic ovarian syndrome (PCO) is characterized by hyperandrogenic
> chronic anovulation, theca cell hyperplasia, and arrested follicular
> development. The aim of this observational study was to determine
> whether vitamin D and calcium dysregulation contribute to the
> development of follicular arrest in women with PCO, resulting in
> reproductive and menstrual dysfunction. Thirteen premenopausal women
> (mean age 31 +/- 7.9 years) with documented chronic anovulation and
> hyperandrogenism were evaluated. Four women were amenorrheic and nine
> had a history oligomenorrhea, two of whom had dysfunctional bleeding.
> Nine had abnormal pelvic sonograms with multiple ovarian follicular
> cysts. All were hirsute, two had alopecia, and five had acanthosis
> nigricans. The mean 25 hydrovitamin D was 11.2 +/- 6.9 ng/ml [normal
> (nl): 9-52], and the mean 1,25 dihydroxyvitamin D was 45.8 +/- 18 pg/ml.
> with one woman with a 1,25 dihydroxyvitamin D <5 pg/ml (nl: 15-60). The
> mean intact parathyroid hormone level was 47 +/- 19 pg/ml (nl: 10-65),
> with five women with abnormally elevated parathyroid hormone levels. All
> were normocalcemic (9.3 +/- 0.4 mg/dl). Vitamin D repletion with
> calcium therapy resulted in normalized menstrual cycles within 2 months
> for seven women, with two experiencing resolution of their dysfunctional
> bleeding. Two became pregnant, and the other four patients maintained
> normal menstrual cycles. These data suggest that abnormalities in
> calcium homeostasis may be responsible, in part, for the arrested
> follicular development in women with PCO and may contribute to the
> pathogenesis of PCO.
>
> Interesting yeah!!
![[ PCOS Discussion Forums ]](../../images/pcos_at_obgyn.gif)