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Re: PCOS article
From: anonymous (anonymous@obgyn.net)
Fri, 14 Jun 2002 01:22:51 -0500 (CDT)
So this must be the reason, regardless of diet and exercise, I can't get
rid of the flabby abdomen :o(!
At Thu, 13 Jun 2002, Victoria wrote:
>
><a href="http://www.endolinx.com/thearts.cfm?artid=366018&specid=16">Developmental
>origin of polycystic ovary syndrome - a hypothesis</a>
>
>The resulting hyperandrogenism results in "programming" of the hypothalamic-
>pituitary unit to favour excess LH secretion, and encourages preferential
>abdominal adiposity that predisposes to insulin resistance. The severity of
>hyperinsulinaemia and insulin resistance (which has a profound influence on the
>phenotype of PCOS) is further influenced by both genetic factors (such as
>polymorphism in the insulin gene regulatory region) and environmental factors,
>notably obesity. This hypothesis therefore suggests a unifying, "linear" model
>to explain the aetiology of the heterogeneous phenotype...
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