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PCOS article From: Victoria (anonymous@obgyn.net) Thu, 13 Jun 2002 14:25:01 -0400 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: anonymous: "Re: PCOS article" Previous message: anonymous@obgyn.net: "Re: diet" Next in thread: anonymous: "Re: PCOS article" Reply: anonymous: "Re: PCOS article" <a href="http://www.endolinx.com/thearts.cfm?artid=366018&specid=16">Developmental origin of polycystic ovary syndrome - a hypothesis</a> The resulting hyperandrogenism results in "programming" of the hypothalamic- pituitary unit to favour excess LH secretion, and encourages preferential abdominal adiposity that predisposes to insulin resistance. The severity of hyperinsulinaemia and insulin resistance (which has a profound influence on the phenotype of PCOS) is further influenced by both genetic factors (such as polymorphism in the insulin gene regulatory region) and environmental factors, notably obesity. This hypothesis therefore suggests a unifying, "linear" model to explain the aetiology of the heterogeneous phenotype... Next message: anonymous: "Re: PCOS article" Previous message: anonymous@obgyn.net: "Re: diet" Next in thread: anonymous: "Re: PCOS article" Reply: anonymous: "Re: PCOS article"

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