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Re: please helpFrom: Virginia (anonymous@obgyn.net)Wed, 20 Jun 2001 05:30:34 -0500 (CDT)
Dear Apparently Metformin is good for blood clot patients and helps reduce weight? Anybody out there on this who has experience - your input would be appreciated. I sent a copy of your last answer with some questions of my own - I am suffering from almost daily bleeding as well as the history of blood clots - below is his reply. He is a very good doctor and very honest. I prefer the blunt truth to bull****. Glucophage is an anti-diabetic drug used in the management of Type II or so called late-onset diabetes. I have not heard of it's use in pure PCOS. Maybe it will help to control the weight aspect of PCOS. In many cases of PCOS there is a glusose intolerance as well, maybe that is what Regan is talking about. The "anti-male' hormone is well known in SA. It is called Androcur and is used to oppose the effects of the increased secretion of Androgens that cause the acne and increased hair growth(hirsutism) associated in some cases of PCOS. It is used on it's own in high doses or combined with oestrogen in a pill called Dianne 35 which will not work for you. Androcur is not a CURE but a management modality and is quite expensive. It will not rectify your bleeding problems. There is NO cure for PCOS yet. All treatments are aimed at managing some of the symptoms. Hysterectomy will only help to stop the bleeding aspect as you will never again have bleeding. It is very often used for this reason in order to improve quality of life but will only deal with the bleeding aspect. One of the first treatments was a so-called wedge resection of the ovaries where a portion of the ovaries are removed or destroyed by cautery(burning). It is almost never used anymore because of less invasive medical management (this is mostly not for you with clotting problems). The only hormonal therapy that you could use with reasonable safety is Progestogen in the form of Depo-provera, Nur-Isterate, or various more expensive oral types. As you can see PCOS is a very complex problem mainly because it is not a disease but abnormal physiology. The old term for this was Stein-Leventhal Syndrome and one variant of this is also called Hyper-thecosis. Sorry that I can not be a little less honest but I do not believe that one should soften reality by giving false hope.
-- Cheers
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