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Amoxicillin or erythromycin for the treatment of antenatal chlamydialFrom: Dr. Sergio P. Ramos (sergioramos@iname.com)Tue, 30 Sep 1997 00:54:59 -0300
Para o Dr Joao Deda que perguntou a respito do tratamento de Clamidia: Amoxicillin or erythromycin for the treatment of antenatal chlamydial infection: a meta-analysis. Author Turrentine MA; Newton ER Address Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Health Science Center, Houston, USA. Source Obstet Gynecol, 1995 Dec, 86:6, 1021-5 Abstract OBJECTIVE: To compare the effectiveness of amoxicillin and erythromycin for the treatment of antenatal Chlamydia trachomatis infection by meta-analysis of available trials involving random assignment of subjects. DATA SOURCES: A computer search of English-language abstracts using MEDLINE and the Cochrane Pregnancy and Childbirth Database (medical subject heading terms: pregnancy, chlamydia, erythromycin, amoxicillin, antenatal antibiotics) was supplemented with a review of the bibliographies of the relevant articles generated by the computer search. METHODS OF STUDY SELECTION: Five trials were identified, four of which met our inclusion criteria for the meta-analysis. DATA EXTRACTION AND SYNTHESIS: Trials to be included in this meta-analysis underwent trial quality evaluation and data abstraction. An estimate of the relative risk (RR) was calculated for the dichotomous outcomes using a fixed-effects model. The pooled RR for the effectiveness of amoxicillin compared with erythromycin was 1.11 (95% confidence interval [CI] 1.05-1.18), and the pooled RR for gastrointestinal side effects of amoxicillin compared with erythromycin was 0.29 (95% CI 0.20-0.42). The pooled RR for gastrointestinal side effects that resulted in discontinuation of therapy of amoxicillin compared with erythromycin was 0.14 (95% CI 0.06-0.36). CONCLUSION: The available data suggest that amoxicillin is more effective than erythromycin for the treatment of antenatal C trachomatis infection and has fewer gastrointestinal side effects, leading to better compliance. Language of Publication English Dr. Sergio dos Passos Ramos Sao Jose dos Campos - SP - Brasil sergioramos@iname.com sergiopr@valley-bbs.com.br Visite a pagina de Ginecologia e Obstetrmcia: http://www.valley-bbs.com.br/sergiopr/
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