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trabalhos interessantes XIIFrom: Jaime (jaimen@zaz.com.br)Sat, 12 May 2001 22:18:32 -0300
Aos colegas da lista As mulheres portadoras de anticorpos Anti CMV, ao contrário do que se pensava não estão protegidas contra uma reinfecção, podem ser portanto reinfectadas com nova carga viral de cepa diferente e transmitir o CITOMEGALOVIRUS ao feto. Trabalho publicado no New England Journal of Medicine no dia 03 de Maio de 2001, sugere que há risco ao feto mesmo quando a mãe for imune. MAIS DETALHES: Pregnant Women Can Pass New CMV Strains to Fetus WESTPORT, CT (Reuters Health) May 03 - Pregnant women with preconceptual immunity to cytomegalovirus (CMV) are not protected against infection with a new strain of the virus and may also transmit it to their infants, according to results from a new study published in the May 3rd issue of the New England Journal of Medicine. "It has been thought that once an individual has been infected with CMV, that person is immune or protected against reinfection," study director Dr. Suresh B. Boppana told Reuters Health. "The results of our study...suggest that, contrary to the current thinking, even seropositive women can be reinfected with different strain of CMV and can pass the newly acquired strain to the fetus." Dr. Boppana, of the University of Alabama at Birmingham, and colleagues examined anti-CMV antibodies from 46 pregnant women with preconceptual immunity to CMV. Of these women, 16 delivered CMV-infected infants. The researchers also characterized CMV isolates obtained from seven of the infected infants. "We found that 62% of the mothers of infants with congenital CMV infection had acquired antibodies with new specificities, as compared with 13% of the mothers whose infants were not infected," the investigators write. In four cases of intrauterine transmission, maternal neutralizing antibodies against CMV matched epitopes from CMV strains isolated from their infants. Thus, previously immune women who acquire new strains of CMV during pregnancy can, in fact, transmit these strains to their infants. The findings have important implications for counseling women with preconceptual immunity to CMV about the risk of intrauterine transmission of the virus, Dr. Boppana told Reuters Health. "In the past, most physicians including us have reassured women who are CMV-seropositive that the risk of neurological damage in their child is very low and minimal." These and other new data "suggest that there is some risk to the fetus even when the mother is immune." The findings also suggest that there may be a need to shift current thinking about the development of anti-CMV vaccines, Dr. Boppana added. "Most of the vaccine efforts at present are directed toward prevention of primary CMV infection during pregnancy, based on the premise that if we prevent primary infections, we can prevent or reduce the number of children with neurological damage from congenital infection." N Engl J Med 2001;344:1366-1371.
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Jaime Nonato http://www.geocities.com/jjndo jaimen@zaz.com.br
Voltar para Administrador da lista: flavio.monteiro.desouza@obgyn.net Solicitações à lista: obstet-l-request@obgyn.net Última atualização: Mon May 19 16:34:15 2008 |
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