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trabalhos interessantes VIIFrom: Jaime (jaimen@zaz.com.br)Fri, 16 Feb 2001 10:28:53 -0300
Aos colegas da lista Low-Dose Aspirin May Help Prevent Preeclampsia Baixa dose de Aspirina pode ajudar a prevenir a Pré eclampsia Eis que após ser descartada até mesmo por vários estudos brasileiros, o British Medical Journal publicou em 08 de Fevereiro, um estudo sobre a baixa dose de aspirina e a prevenção da pré eclampsia. A Dra. Lea Duley de Oxford, Inglaterra - reviu 39 estudos randomizados englobando 30.563 mulheres com risco de pré eclampsia. Encontrou moderado benefício no uso do método que segundo a autora, não deve ser desprezado. Ela encontrou: 15% de redução no risco de pré eclampsia. 8% de redução de partos prematuros. 14% de redução de morte neonatal. Mais detalhes WESTPORT, CT (Reuters Health) Feb 08 - Antiplatelet drugs, primarily low-dose aspirin, appear to offer moderate benefit in the prevention of preeclampsia, according to a report published in the February 10th issue of the British Medical Journal. Dr. Lelia Duley from the Institute of Health Sciences in Oxford, UK and colleagues assessed the safety and efficacy of antiplatelet drugs in preventing preeclampsia and its consequences by performing a systematic review of 39 randomized trials that investigated the issue and met selection criteria. These trials included 30,563 women at risk for preeclampsia. The investigators found a 15% reduction in the risk of preeclampsia with antiplatelet drug use. In addition, an 8% reduction in the risk of preterm birth and a 14% reduction in the risk of fetal or neonatal death were noted in women taking these medications. There was no significant difference in the incidence of small for gestational age babies or other outcome measures between the groups. "As the reductions in risk are moderate, relatively large numbers of women will need to be treated to prevent a single adverse outcome," the researchers point out. "From a public health perspective, however, even these moderate benefits may be worthwhile." Dr. Duley and colleagues warn that "starting treatment before 12 weeks and using higher doses cannot be recommended until more information is available about safety." BMJ 2001;322:329-333.
-- Jaime Nonato http://www.jaimenonato.com jaimen@zaz.com.br
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