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trabalhos interessantes IIFrom: Jaime (jaimen@zaz.com.br)Thu, 25 Jan 2001 23:02:52 -0200
Aos colegas da lista Fatores genéticos contribuem largamente para o desenvolvimento do câncer do colo uterino. Uma publicação do "International Journal of Cancer" - de Dez/2000. Aborda a influência dos fatores genéticos no desenvolvimento do câncer de colo. destaques: 1- Os fatores genéticos podem explicar o motivo pelo qual somente uma minoria de mulheres expostas às formas oncogênicas do HPV desenvolvem câncer. 2- É mais evidente a relação irmã/irmã do que mãe/filha. 3- A hereditariedade do câncer de colo é mais significativa do que no de pulmão, no de coloretal e no melanoma. Veja mais. WESTPORT, CT (Reuters Health) Dec 12 - The development of cervical tumor is largely influenced by predisposing genetic factors rather than environmental variables, according to a report published in the December issue of the International Journal of Cancer. This finding may explain why only a minority of women infected with human papillomavirus (HPV) develop cervical cancer, the authors state. Dr. Patrik K. E. Magnusson, from the University of Uppsala, in Sweden, and colleagues analyzed genetic and environmental influences on tumor development in subjects who were biologically or adoptively related to patients with cervical tumors, and in age-matched control subjects. On analysis, the investigators found that shared genes explained 27% of the variability in susceptibility to cervical disease. Shared family environment showed a significant, albeit small, effect for sister relations, but not for mother/daughter relations. The heritability for cervical tumors in the current study "was substantially higher than that for colorectal cancer, lung cancer, and melanoma when a similar method was applied to the same population," the researchers state. "This is of considerable interest since in melanoma and colorectal cancer a genetic component has long been recognized and predisposing genes have been identified in a subset of cases." "How much of the genetic predisposition to cervical tumors is due to susceptibility or sensitivity to HPV is not known, but it could be a major factor. Many women are never exposed to oncogenic forms of HPV; thus, the estimated importance of inherited genetic factors could be much larger if measured in HPV-exposed women only," Dr. Magnusson's team emphasizes. "The task of identifying the genes contributing to an increased risk for cervical tumours, as for any multifactorial disease, is far from trivial. Once identified, such genetic factors may be of great value for the handling of patients with early stages of neoplasia," the authors conclude. Int J Cancer 2000;88:698-701.
-- Jaime Nonato http://www.jaimenonato.com jaimen@zaz.com.br
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