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Re: Pintura de cabeloFrom: Ricardo Savaris (savaris@orion.ufrgs.br)Tue, 12 Dec 2000 23:49:42 -0200
REferencias : TITLE: Heritable translocation study on two hair dye formulations. AUTHORS: Burnett C; Loehr R; Corbett J SOURCE: Fundam Appl Toxicol 1981 Jul-Aug;1(4):325-8 CITATION IDS: PMID: 7185580 UI: 83288153 ABSTRACT: Sexually mature Charles River Sprague Dawley CD outbred male rats received topical applications of hair dyes twice weekly for 10 weeks. They were then mated to one sexually mature female of the same strain each week for three weeks. One hundred F1 males from these matings, maintained under standard conditions for 12 weeks, were paired with one mature female per week for three weeks. The pregnancies were interrupted after approximately 16 days and the numbers of live and dead fetuses and implantations and resorptions were recorded. Fertility rates were high for both generations. Average litter sizes for the two hair dye groups and the control in the F1 generation were nearly identical and were in excess of 11 live pups per litter. There is no evidence from these results that frequent topical applications of hair dyes cause stable chromosomal rearrangements, such as translocations, which may result in reduced fertility of the offspring of the treated subject. TITLE: Teratology and percutaneous toxicity studies on hair dyes. AUTHORS: Burnett C; Goldenthal EI; Harris SB; Wazeter FX; Strausburg J; Kapp R; Voelker R SOURCE: J Toxicol Environ Health 1976 Jul;1(6):1027-40 ABSTRACT: Twelve hair dye formulations were tested for systemic toxicity by topical application twice weekly for 13 wk to groups of 12 New Zealand white rabbits and for teratologic effects following applications to groups of 20 pregnant Charles River CD rats on days 1, 4, 7, 10, 13, 16, and 19 of gestation. The three semipermanent formulations were applied as is, and the nine oxidation dyes were mixed 1:1 with 6% hydrogen peroxide just prior to application, as in normal use. The formulations induced a broad spectrum of dyes and dye intermediates used or considered useful in oxidative and semipermanent hair color products. In the teratology study no biologically significant soft tissue or skeletal changes were noted. Similarly, the mean numbers of corpora lutea, implantation sites, live fetuses, and resorptions per pregnancy, as well as numbers of litters with resporptions, were not significantly affected by the dye treatment. In the percutaneous toxicity study there was no evidence of compound-induced systemic effects. Microscopic examination of 25 tissues from each animal gave no indication of histomorphologic evidence of toxicity. No dye discoloration of urine was seen at any time during the test or at necropsy. Some of the dye groups showed epidermal hyperplasia, which was probably a reflection of slight irritation due to the frequency of application of the oxidation formulations.
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