Re: Hepatitis caused by Provera?

From: Myer S. Bornstein, MD, CPE, FACOG (mborn@massmed.org)
Sat Oct 30 10:45:24 1999


The PDR have cholostatic Jaundice as a adverse reaction to Provera and that it is contraindicated in a patient with liver dysfunction Myer

-----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net]On Behalf Of Jane Helwig, MD Sent: Friday, October 29, 1999 10:11 PM To: Multiple recipients of list OB-GYN-L Subject: Hepatitis caused by Provera?

Recently I started a 400+lb amenorrheic patient on Provera 10mg daily for 10 days. Several days after starting the Provera she developed severe nausea. Transaminases were elevated into the 1000's. All viral hepatitis antibody titers negative, no gallstones on ultrasound. Since she finished the 10 days of Provera, the transaminases are dropping.

Her internal medicine doctor is blaming the Provera for the hepatitis. The patient can't take oral contraceptives because she becomes hypertensive. She is a nulligravida so I don't think she is a candidate for Progestasert IUD.

Questions: Have you ever known Provera to cause hepatitis? What alternate source of progestin would you use?

Thanks.

--
Jane Helwig, MD
Private practice
Nassawadox, VA




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