FW: CROSS-POST[Ovary-Science] egg donation and mirena IUS

From: Jeffrey W. Clemens (clemens@duq.edu)
Thu Oct 28 07:28:23 1999


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Listers,

Can anyone help this person out? Inquiry was posted to the ovary-science list. Please respond to that list or Jonathon directly, NOT TO ME. I have no other info. about this individual.

--
Jeffrey W. Clemens, Ph.D.
Assistant Professor, Biological Sciences
Duquesne University
Pittsburgh, PA 15282
412-396-4597
fax-5907
http://www.home.cc.duq.edu/~clemens/

---------- From: "Jonathan" <jonathan.skull@lineone.net> To: <ovary-science@nottingham.ac.uk> Subject: [Ovary-Science] egg donation and mirena IUS Date: Wed, Oct 27, 1999, 6:26 PM

I have a lady who wants to act as an altruistic anonymous egg donor, but has a Mirena IUS fitted for both contraception and mennorrhagia. It has been in situ for 5 months and is providing excellent cycle control.

My question is "should this be removed before attempting superovulation". The easy answer would be "yes" and replace it afterwards. However, I am reluctant for three main reasons: She requires good contraception She requires control of her periods and to have a recurrence of her bleeding problems may dissuade her from being an egg donor. The cost of replacement may have to be born by the General Practitioner, who having only just having put the coil in, may be none too pleased! However, I would not want to leave it in-situ if it could affect the response to superovulation or the quality of the oocytes and resultant embryos leading to decreased pregnancy rates in the recipient.

Enquires to the manufacturer (Schering) reveal that serum levels of Levonorgestrel (LNG) reach maximum levels within a few hours of insertion and reach a plateau of 100-200 pg/ml after the first few weeks (Haukkamaa et al. 1996).

I can find no literature on this subject and wondered if anybody else has had experience with this or has any advice.

Many thanks

--
Jonathan Skull




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