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Re: hormone replacement and s/p tah bsoFrom: Ronald E. Ainsworth (ainsron@msn.com)Tue Oct 26 20:01:58 1999
>1. What does the latest date suggest on unopposed Estrogen in a post-menopausal woman with tah/bso, and no family history of breast ca and no other risk factors, in increasing her risk for breast ca? Progestogens (progesterone, provera, norlutate, ...) do not reduce the risk of breast cancer. This idea was suggested in the 70's but studies have not been conclusive. >2. Is replacement of progesterone in a woman without a uterus necessary for other reasons, physiologically. The only argument that holds any water in my mind is for the woman who had a hysterectomy for endometriosis. Unopposed estrogen has the "potential" to cause endometrial cancer in any unresected areas. On the other, I do not routinely use progestogens in those patients and have never seen endometrial type of CA in them after hysterectomy.
-- Ronald E. Ainsworth, MD, FACOG
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