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Re: Finasteride in pregnancyFrom: Ronald E. Ainsworth (ainsron@msn.com)Fri Aug 27 10:24:19 1999
At Thu, 26 Aug 1999, James Brodribb wrote: > >Exposure to finasteride (Propecia) from conception to 8 weeks. Does anyone have >experience of this situation? I'm sure you have already looked it up in the PDR, it is classified as a category X for pregnancy. No abnormalities were noted in female offspring in rats, but males were effected with a high rate of development of hypospadias (3.6-100%). The critical period in rats was day 16-17 of gestation. It caused changes similar to Type II 5a reductase defeciency. Studies on rabbits did not show similar developmental changes, but high doses in rhesus monkeys did result in external genital abnormalities (100 times the recommended human dose). I would doubt that these risks would be an acceptable reason for termination for most patients.
-- Ronald E. Ainsworth, MD, FACOG Paradise, CA, Private Practice 20 yrs.
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