Re: ?premature menopause

From: Shankar Periasamy (shankar@pc.jaring.my)
Tue Aug 3 07:48:21 1999


Subject: ?premature menopause

>I have a 29 years old patient recently married with a history of
>very high FSH and LH with FSH of about 70 - 80 IU/L and LH of 30 - >40 IU/L
on repeated occasions.All other hormonal profiles are >normal. She has no menopausal symptoms.

>Is she truly menopause? What is her possible diagnosis?

May be FSH-receptor mutation. Case has been reported by Aittomoki et al. They've also successfully induced ovulation using rFSH and achieved pregnancy.

>My question is in view of her having spontaneous period albeit >irregular
signifying a well estrogenised endometrium and by >implication not estrogen depleted, does she still need estrogen >replacement therapy?

May be not.

Take Care

Bye

Shankar shankar@pc.jaring.my

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ "Failure obliges change. Success breeds complacency and fear of change. Hence success contains the seeds of failure." ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~





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