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Re: estrogen From: Braun, R. Daniel (rbraun@iupui.edu) Mon Aug 2 12:43:21 1999 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: james connerth: "Re: estrogen" Previous message: james connerth: "Re: Behcet's disease and OC's" Right, but the other half of my point was that there are some people who actually require 1.25 to get bone protection. Therefore reducing to 0.375 would decrease the number of people getting protection. Dan R. Daniel Braun, MD FACOG Clinical Professor Department of Obstetrics and Gynecology Indiana U. School of Medicine Indianapolis, IN 46202 International Representative for United States OBGYN.net -----Original Message----- From: Zach Newton [mailto:zbnewton@mindspring.com] Sent: Saturday, July 31, 1999 10:05 PM To: Multiple recipients of list OB-GYN-L Subject: Re: estrogen "Braun, R. Daniel" wrote: > > I thought the studies showed that there was bone protection in 90% of > patients with 0.625. That would mean that 10% require even more than 0.625. Dan- So much involved here. The confounding factors overwhelm any capacity to sort it all out. At any given dosage of any estrogenic agent, there is variability of: 1. Absorption 2. Adherence to dosing schedule 3. Hepatic metabolism on first pass for oral agents 4. Estrogen receptor distribution and density 5. Potency and action of metabolites of absorbed estrogenic agent 6. Genetics 7. Life style 8. Co-morbidity 9. Interaction with other drugs, supplements and diet 10. Half-life of major circulating metabolites 11. Concentration levels of free metabolites 12. And so on Given all this, there is no theraputic alternative that has equal or superior results documented for long term use to yield the positive results with the safety profile of Premarin at the 0.625 dosage. -- Zach Newton Z, B. Newton, III, M.D. Atlanta/Gyn Next message: james connerth: "Re: estrogen" Previous message: james connerth: "Re: Behcet's disease and OC's"

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