Re: Anticoagulation and surgery

From: Anthony Evans (ahcevans@execpc.com)
Thu Apr 29 09:09:29 1999


On Thu, 29 Apr 1999 00:00:28 -0500, "Madhumita Roy" <madhumita_roy@hotmail.com> wrote:

>29th April, 1999
>
>I have a 40 year old patient who has a small left adnexal,
>possibly ovarian mass(4 cm). She has a prosthetic mitral valve and
>takes Nicoumalone and low dose aspirin for anticoagulation. If she
>ever needs surgery what should be the safe INR? Secondly, how safe is
>laparoscopy in these situation - she has good cardiac function. At
>present I am not planning to do anything, but in case she needs any
>intervention, say for an increase in the size of the mass or
>developement of pain, what precautions should I take? Can any one
>help?
>Thanks

I usually stop the warfarin about 3 days before surgery and recheck the INR (I would want it under 1.3 at least). If she cannot afford to be off for that long...admit to the hospital the night before, administer fresh frozen plasma until the anticoagulation has been reversed, and do surgery first thing in the AM. In general, it is a bad idea to use vitamin K...can be very hard to anticoagulate post-op when the warfarin is resumed.

Post-op, I would start heparin about 24 hours later (could be earlier if there is minimal bleeding or raw surfaces) and restart warfarin the evening of POD #1 or #2. Then d/c heparin as usual when INR is in the appropriate range.

It is probably unnecessary to stop the low dose aspirin but you could check a bleeding time to be cautious.

Laparoscopy should be tolerated well if the mitral valve is the only issue.

Craig Evans, M.D., Ph.D. Vince Lombardi Cancer Clinic Milwaukee, WI





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