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Re: Solid ovarian massFrom: Anthony Evans (ahcevans@execpc.com)Mon Mar 29 15:53:08 1999
On Mon, 29 Mar 1999 15:32:57 -0600, Ealgail@aol.com wrote:
> My most recent ovarian cancer, a stage !A, had a NORMAL CA-125 pre- About one-half of women with stage 1 tumors have CA125 less than 65. This is one of the reasons that it is a poor SCREENING test. However, recurrences may cause elevation even when the primary tumor did not. Therefore, it is still advisable to follow women post-op with this test.
> I get one pre-operatively so that the oncologists can follow the drop The rate of fall of CA125 gives prognostic information. Favorable prognostic signs include normalization of CA125 within 3 months (predicting neg 2nd look procedures), 7-fold drop by 60 days (prolonged time to recurrence), and CA125 half-life of less than 20 days (improved survival). It is debated whether rise of CA125 after remission is uniformly diagnostic of recurrence. For the first elevation, I usually prefer to have histologic confirmation before commiting the patient to further chemo. For subsequent elevations, I re-treat based on clinical and radiologic criteria. ------------------------------- Craig Evans, M.D., Ph.D. ------------------------------- Vince Lombardi Cancer Clinic -- ------------------------------- Milwaukee, WI
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