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Re: Advice on normal serum AFP, elevated amniotic fluid AFP? "reply"From: AFPPLUS3@aol.comFri Mar 26 07:58:58 1999
In a message dated 3/25/99 1:24:31 PM Eastern Standard Time, aleeoc@rocketmail.com writes: << How would you manage a patient with a normal triple screen >> First I would ask the question why did the patient elect to have an amnio? While you are correct that patients with an "elevation" of their AFAFP value and a cause is not found some finding might reveal itself later in the pregnancy. You indicate that the fetal hemoglobin (HbF) was negative, do you know how they determine the presence of HbF? Was the amniotic fluid (AF) bloody? Some techniques are not sensitive enough to measure HbF in AF. Now that I have said all of this the one question that I would really like to know the answer to is in this case what are the number in which the laboratory finds AF samples with an AFP above 2.0 MoM? And what is their median MoM, (for weeks 15 - 21) of patients being tested over the last few months for when this patients was tested. A small shift in the normative data (downward) in the laboratory data base may give you the finding you are dealing with. Leonard H. Kellner, MS Administrative Director, Reproductive Genetics Dept. of Obstetrics and Gynecology Montefiore Medical Center, Albert Einstein College of Medicine
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