-VISIT OUR OTHER FORUMS- OB-GYN-L Ultrasound Ultrasound History Fibroid Forum Physicians-in-Training Tech Talk OBSTET-L (portuguese) OBGIN-L (spanish) Nursing

Re: Advice on normal serum AFP, elevated amniotic fluid AFP? From: Braun, R. Daniel (rbraun@iupui.edu) Fri Mar 26 07:10:04 1999 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Braun, R. Daniel: "Re: Pre-implantation diagnosis and balanced translocation" Previous message: Karen D. Kudia: "How would you watch more carefully?" Maybe in reply to: annette lee: "Advice on normal serum AFP, elevated amniotic fluid AFP?" Now we have a series of 4 pregnancies in two women. Since both our patients had it happen in two successive pregnancies, it makes you wonder is this an inherited or genetic trait of some kind.?????????????? Dan R. Daniel Braun, MD FACOG Clinical Professor Department of Obstetrics and Gynecology Indiana U. School of Medicine Indianapolis, IN -----Original Message----- From: Tony Blair [SMTP:antoineb@globetrotter.qc.ca] Sent: Friday, March 26, 1999 5:01 AM To: Multiple recipients of list Subject: Re: Advice on normal serum AFP, elevated amniotic fluid AFP? -----Message d'origine----- De : annette lee <aleeoc@rocketmail.com> À : Multiple recipients of list <ob-gyn-l@talk.obgyn.net> Date : jeudi 25 mars 1999 13:28 Objet : Advice on normal serum AFP, elevated amniotic fluid AFP? >How would you manage a patient with a normal triple >screen who underwent genetic amnio at 16 weeks (well >dated by LMP and first trimester sono) and was found >to have nl 46XY karyotype but AMNIOTIC fluid AFP >2.1 MOM. Amniotic fluid negative for fetal hemaglobin >ruling out contamination with fetal blood. >Acetylcholinesterase negative and no evidence of >renal, neural tube or GI abnormality on level 2 scan? >A quick medline search suggests that this is either a >false positive, could indicate increased risk of >pre-eclampsia or very subtle neural tube defect. The >patient is a physician to boot. > ############################################################### I had the same problem in 2 successives pregnancies for the SAME patient. Elevated AFP in amniotic fluid without any blood contamination. Amniocentesis done for maternal age (37 for the 1st pregnancy and 39 for the 2nd). Evaluation in a tertiary center was absolutely negative. First vaginal delivery at 36 weeks (premature labor): normal male 7#14oz...big for age. Healthy at 2½ y.o. Second vaginal delivery at 38 weeks on 99-03-24: normal female 9#5oz. Gestational diabetes on 3rd trimester tx with insulin QID. The baby seems normal but only 2 days old! No other anomaly with the 2 pregnancies. I think you can re-assure your patient. Incidentally, the consultant in the tertiary center and the genetist had no explanation for this disturbing 'curiosity' Hope this will help. Tony Blair md ( not the UK - PM ! ) Ob/Gyn Canada Next message: Braun, R. Daniel: "Re: Pre-implantation diagnosis and balanced translocation" Previous message: Karen D. Kudia: "How would you watch more carefully?" Maybe in reply to: annette lee: "Advice on normal serum AFP, elevated amniotic fluid AFP?"

Return to

Mail a New Message to the Forum: ob-gyn-l@obgyn.net Forum Administrator: geffrey.klein@obgyn.net Report Technical Problems: webmaster@obgyn.net Last Updated: Wed Dec 2 05:27:54 2009

The American Medical Association is no longer designating CME hours for AMA Category II CME credit. However, physicians themselves may self designate learning activities as Category II CME credit hours if they feel it is of sufficient educational merit and meets the formal definitions of continuing medical education. OBGYN.net believes these interaction in this forum meets these criteria. For further information see the AMA web site.