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Re: Advice on normal serum AFP, elevated amniotic fluid AFP? From: Tony Blair (antoineb@globetrotter.qc.ca) Fri Mar 26 02:59:13 1999 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Braun, R. Daniel: "Re: Pre-implantation diagnosis and balanced translocation" Previous message: Roberta Speyer: "Pregnancy and Birth March Update" Maybe in reply to: annette lee: "Advice on normal serum AFP, elevated amniotic fluid AFP?" Next in thread: Braun, R. Daniel: "Re: Advice on normal serum AFP, elevated amniotic fluid AFP?" -----Message d'origine----- De : annette lee <aleeoc@rocketmail.com> À : Multiple recipients of list <ob-gyn-l@talk.obgyn.net> Date : jeudi 25 mars 1999 13:28 Objet : Advice on normal serum AFP, elevated amniotic fluid AFP? >How would you manage a patient with a normal triple >screen who underwent genetic amnio at 16 weeks (well >dated by LMP and first trimester sono) and was found >to have nl 46XY karyotype but AMNIOTIC fluid AFP >2.1 MOM. Amniotic fluid negative for fetal hemaglobin >ruling out contamination with fetal blood. >Acetylcholinesterase negative and no evidence of >renal, neural tube or GI abnormality on level 2 scan? >A quick medline search suggests that this is either a >false positive, could indicate increased risk of >pre-eclampsia or very subtle neural tube defect. The >patient is a physician to boot. > -- ############################################################### I had the same problem in 2 successives pregnancies for the SAME patient. Elevated AFP in amniotic fluid without any blood contamination. Amniocentesis done for maternal age (37 for the 1st pregnancy and 39 for the 2nd). Evaluation in a tertiary center was absolutely negative. First vaginal delivery at 36 weeks (premature labor): normal male 7#14oz...big for age. Healthy at 2½ y.o. Second vaginal delivery at 38 weeks on 99-03-24: normal female 9#5oz. Gestational diabetes on 3rd trimester tx with insulin QID. The baby seems normal but only 2 days old! No other anomaly with the 2 pregnancies. I think you can re-assure your patient. Incidentally, the consultant in the tertiary center and the genetist had no explanation for this disturbing 'curiosity' Hope this will help. Tony Blair md ( not the UK - PM ! ) Ob/Gyn Canada Next message: Braun, R. Daniel: "Re: Pre-implantation diagnosis and balanced translocation" Previous message: Roberta Speyer: "Pregnancy and Birth March Update" Maybe in reply to: annette lee: "Advice on normal serum AFP, elevated amniotic fluid AFP?" Next in thread: Braun, R. Daniel: "Re: Advice on normal serum AFP, elevated amniotic fluid AFP?"

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