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Re: Advice on normal serum AFP, elevated amniotic fluid AFP? From: Malcolm Griffiths (Malcolm@MGRIFF22.demon.co.uk) Thu Mar 25 23:52:52 1999 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Malcolm Griffiths: "Complaint (was: BMJ -- 318 (7187): 0)" Previous message: Mario Colombo, MD: "R: Ecological HRT" In reply to: annette lee: "Advice on normal serum AFP, elevated amniotic fluid AFP?" Next in thread: Tony Blair: "Re: Advice on normal serum AFP, elevated amniotic fluid AFP?" In message <19990325182106.18318.rocketmail@web4.rocketmail.com>, annette lee <aleeoc@rocketmail.com> writes >How would you manage a patient with a normal triple >screen who underwent genetic amnio at 16 weeks (well >dated by LMP and first trimester sono) and was found >to have nl 46XY karyotype but AMNIOTIC fluid AFP >2.1 MOM. Can I ask you a question? Why did she have an amnio if her triple test was negative? Or put another way why do a triple if your going to do an amnio anyway? To answer your question: 2.1MoM is not excessiively elevated - we'd use a cut-off of >2.5 or even 3.0. My understanding would be that inc risk of pre-eclampsia or IUGR is associated with increased levels of maternal SERUM AFP, as it is said to reflect a breach of the materno-fetal/placental interface. I suppose I'd watch her a bit more carefully, but wouldn't expect any problems. Malcolm Griffiths MD,MRCOG,MFFP,Cert.Mgmnt Obstetrician & Gynaecologist Luton & Dunstable Hosp.,UK. Tel: 01582-497459 (office) Fax: 01582-497376 01525-222849 (home) email: Malcolm@mgriff22.demon.co.uk http://www.obgyn.net/board/griffith.htm "CLINICAL FREEDOM IS THE LAST REFUGE OF THE CLINICALLY INCOMPETENT!" (Tuffnell [1997]) Next message: Malcolm Griffiths: "Complaint (was: BMJ -- 318 (7187): 0)" Previous message: Mario Colombo, MD: "R: Ecological HRT" In reply to: annette lee: "Advice on normal serum AFP, elevated amniotic fluid AFP?" Next in thread: Tony Blair: "Re: Advice on normal serum AFP, elevated amniotic fluid AFP?"

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