Re: Advice on normal serum AFP, elevated amniotic fluid AFP?

From: Bert Gold (bgold@ktb.net)
Thu Mar 25 20:32:04 1999


I would call George Knight or James Haddow at the Foundation for Blood Research in Scarborough, Maine (developers of AFP for ONTDs) and ask them what they would counsel. Their phone number is: (207) 883-4131 Good Luck.

annette lee wrote: >
> How would you manage a patient with a normal triple
> screen who underwent genetic amnio at 16 weeks (well
> dated by LMP and first trimester sono) and was found
> to have nl 46XY karyotype but AMNIOTIC fluid AFP > 2.1 MOM. Amniotic fluid negative for fetal hemaglobin
> ruling out contamination with fetal blood.
> Acetylcholinesterase negative and no evidence of
> renal, neural tube or GI abnormality on level 2 scan?
> A quick medline search suggests that this is either a
> false positive, could indicate increased risk of
> pre-eclampsia or very subtle neural tube defect. The
> patient is a physician to boot.
>

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Bert Gold, Ph.D. Vita brevis Research and Development Ars longa SmithKline Beecham Occasio praeceps Clinical Laboratories, Inc. Experientia fallax 7600 Tyrone Avenue Judicium dificile Van Nuys, California USA 91405 -Hippocrates bgold@ktb.net bert.gold@sb.com VOICE: 818-376-6332 http://www.ktb.net/~bgold FAX: 818-376-6387

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