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Re: Advice on normal serum AFP, elevated amniotic fluid AFP?From: DoctorJoe@aol.comThu Mar 25 18:45:04 1999
In a message dated 3/25/99 12:24:31 PM, aleeoc@rocketmail.com writes: << How would you manage a patient with a normal triple screen who underwent genetic amnio at 16 weeks (well dated by LMP and first trimester sono) and was found to have nl 46XY karyotype but AMNIOTIC fluid AFP 2.1 MOM. Amniotic fluid negative for fetal hemaglobin ruling out contamination with fetal blood. Acetylcholinesterase negative and no evidence of renal, neural tube or GI abnormality on level 2 scan? A quick medline search suggests that this is either a false positive, could indicate increased risk of pre-eclampsia or very subtle neural tube defect. The patient is a physician to boot. >> Was the screen for fetal hemoglobin definitive? Couldn't there have been an OLD bleed and the hemoglobin was already gone/degraded? What test was run? Second point: You should have KNOWN that a physician would have had some bizarre complication, right??? Joe P.
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