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Re: anal fissures - clinical studyFrom: Dr. Mike Crowley (mcrowley@cellegy.com)Thu Mar 11 12:39:04 1999
Dr. Waldby commented that: >The results with nitroglycerin ointment are variable--some claim success, some get headaches and many state they are not helped. >Gail Waldby, MD >Huron Clinic SD There is good reason to believe that a lack of dose and dosing interval data is significantly contributing to the experiences of certain patients who are not benefiting from nitroglycerin treatment. Therefore determining the lowest dosage of this drug which can promote healing while minimizing side effects such as headache is essential. If properly dosed and standardized, a nitroglycerin ointment is a much more desirable first treatment following diagnosis of an anal fissure than any other treatment, including surgery. It should also be noted that I personally have heard several stories of pharmacy compounded nitroglycerin ointment that has not been uniformly mixed. The viscous nature of the ointment makes it very difficult to mix. If not mixed properly, patients will get variable doses of the medication with each application, and are much more likely to get headaches when more concentrated pockets of nitroglycerin ointment are encountered within a prescription bottle. This is another explanation for the variable results reported for nitroglycerin and is another reason why a uniform, stable, and properly dosed nitroglycerin ointment needs to be developed. Thanks for your interest.
-- Michael P. Crowley, Ph.D. Cellegy Pharmaceuticals, Inc. 349 Oyster Point Boulevard, Suite 200 South San Francisco, CA 94080 (650) 616-2213 mcrowley@cellegy.com
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