Re: anal fissures - clinical study

From: Gail Waldby, MD (gwaldby@willinet.net)
Thu Mar 11 05:42:27 1999


Norman Sohn (New York City Colorectal surgeon) has developed a possibly better treatment for anal fissures that don't heal with medical treatment. He is using controlled anal balloon dilation with a 4 cm wide 6 cm long balloon inflated to 20 psi for 6 minutes.

The results with nitroglycerin ointment are variable--some claim success, some get headaches and many state they are not helped. Gail Waldby, MD Huron Clinic SD

"Dr. Mike Crowley" wrote: >
> Cellegy Pharmaceuticals is conducting a Phase III clinical trial for a
> nitroglycerin ointment (Anogesic®) that promotes the healing of chronic
> anal fissures, a condition typically treated by surgery. The efficacy
> of nitroglycerin treatment of anal fissures has been demonstrated in
> several scientific studies (e.g. Lund et al., Lancet, 1997, 349:9044,
> 11-14). However, the proper dose and dosing interval of nitroglycerin
> required for healing of anal fissures have not been established. Our
> trial is designed to determine these parameters.
>
> This is a national, multicenter study. For more information and a list
> of study centers please visit Cellegy Pharmaceuticals on the Internet
> at:
>
> http://cellegy.com/corp/clinical_trial.html
>
> If you are located near a study center, please consider referring
> patients suffering from a chronic anal fissure, one lasting greater than
> 30 days, to this study. Thank you for your interest.
>
> --
> Michael P. Crowley, Ph.D.
> Cellegy Pharmaceuticals, Inc.
> 349 Oyster Point Boulevard, Suite 200
> South San Francisco, CA 94080
> (650) 616-2213
> mcrowley@cellegy.com





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