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Fatty acidFrom: Peter Wein (p.wein@obsgyn-mercy.unimelb.EDU.AU)Wed Dec 30 16:53:55 1998
>Peter, you don't have to answer this post. I would like to hear your >opinion, as well as those of your distinguished european colleagues, on >the issue I mentioned earlier: maternal floor infarction of the placenta >and possible association with long chain fatty oxidation disorders >(fetal). I've already searched MEDLINE, I need insight from other >sources. > >Luis Sanchez-Ramos, MD > One thing that springs to mind - only hypothesis mind you, not seen anything relating the 2 - is the possible role here of TNF-alpha. It is closely involved in fat metabolism, increased synthesis with increased levels of fatty acids I think, and it is produced in large amounts by the placenta but released into he maternal circulation - where it probably has a role in vascular remodelling as it promotes cell death. Not sure if this is of any practical use though. Luis - the condition is presumably diagnosable antenatally - don't have your original post. If any other pregnancy is similarly affected, the condition being lethal, would the patient request termination of pregnancy, so making the problem irrelevant? If not - heparin and aspirin is my only therapeutic thought. ?Vitamin E a help. Peter Wein
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