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Re: Precocious pubertyFrom: DoctorJoe@aol.comSat Aug 29 12:48:22 1998
In a message dated 8/29/98 10:35:59 AM, you wrote: <<I am treating a 9-year old with monthly Zoladex (goserelin, 3.6mg). It has stopped menstruation and she is growing (currently 146cms), but breast development is continuing. This is a constitutional precocious puberty, with no cause found after extensive investigation. She remains a little girl emotionally, and the breast development is distressing her. I guess its related to persisting low levels of E2 (we know from treatment of Turners that you need low estrogens to promote breast development), but I would welcome any advice.>> If her hypothalamus is sufficiency inhibited, where is the estrogen coming from? Is she "fat" for her age? Is it peripheral conversion? Or does she have a tumor you missed? Otherwise, does she need more drug? Joe P.
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