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Re: Gyn: OCPsFrom: Terrence.Jones@ncal.kaiperm.orgFri Aug 28 16:07:04 1998
Gail, does the current issue of selected readings on DVT/PE prophylaxis mention anything on 'lepirudin'? As You'd mentioned, if on oral coagulant, OCP's are unlikely to pose risk (Comp&Zacur AJOG 6/93, 168:1990-93 {see blurb on bottom rt. on pg 1992 -> OC's might in fact reduce menorrhagia, along with - as Dr. Grimes mentions at times, when not scaring Joe TM with IUD data - hemoperitoneum assoc with ovulation.} This article appears in a supplement titled "Contraceptive Choices for Women with Medical Problems", from a symposium Co-chaired By Drs. Grimes/Mishell/&Speroff. Dr G's last 2 sentences in the first paragraph of his intro echoes the above sentiment.) Don't know of any recent studies specifically addressing the postop ortho Pt. on OC's & coumadin. If following INR, should be able to compensate for any peri-op changes in F VII? Spose there might be some concern re: protein C depletion in those with this mechanism for thrombophilia? tj.
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