-VISIT OUR OTHER FORUMS- OB-GYN-L Ultrasound Ultrasound History Fibroid Forum Physicians-in-Training Tech Talk OBSTET-L (portuguese) OBGIN-L (spanish) Nursing

Re: OB: progesterone From: Peter Wein (p.wein@obsgyn-mercy.unimelb.EDU.AU) Sun Jun 28 00:08:12 1998 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Peter Wein: "Re: Preeclampsia Lab Package" Previous message: RModugno@aol.com: "Re: +3/5 (Long)" In reply to: Malcolm Griffiths: "Re: OB: progesterone" Next in thread: Malcolm Griffiths: "OB: progesterone - reponse to Peter Wein!" Reply: Malcolm Griffiths: "OB: progesterone - reponse to Peter Wein!" At 09:54 AM 27/06/98 -0500, you wrote: >The summary you sent mentions possible benefits in terms of avoiding >preterm birth - requiring multiple injections. The discussion was about >the use of prog in first trimester use to prevent miscarriage. > >Even in this review the beneficial effects show 95% CI for OR which >either reach unity (1.0) or almost do (0.95). In the context that there >are multiple endpoints to address in such studies, many would argue that >a greater degtree of statistical significance is required. (Test 20 >hypoteses on one dataset and it is likely that 5% [ie, one] will reach >stat sign at the 5% level). > >I recall at least two metanalyses addressing prog for rec miscarriage >about three years ago. Both showed no benefit *against recurrent >misscarriage*! >Malcolm Griffiths MD,MRCOG,MFFP,Cert.Mgmnt >Obstetrician & Gynaecologist Luton & Dunstable Hosp.,UK. >Tel: 01582-497459 (office) Fax: 01582-497376 > 01525-222849 (home) email: Malcolm@mgriff22.demon.co.uk >http://www.obgyn.net/board/griffith.htm >"CLINICAL FREEDOM IS THE LAST REFUGE OF THE CLINICALLY INCOMPETENT!" >(Someone [1997]) > Malcolm - your words were "There is no proven benefit of prog supplementation at all outside of assisted conception. Any use otherwise is at best placebo and at worst quack!" - you didn't;mention anything about recurrent miscarriage - nor was this the topic of the original post. I would submit that there is some proven benefit of prog supplementation - be it in avoiding preterm births and requiring multiple injections and all - and just looking at 95% confidence interval is being blinded by statistics - all they mean is that we are 95% sure that the true OR lies within the stated range - but if there is a benefit - do we have to be that sure - in the civil courts all we have to be is more than 50% sure! -- Peter Wein Senior Lecturer Department of Obstetrics and Gynaecology University of Melbourne, Mercy Hospital for Women Clarendon Street, East Melbourne 3002 Australia Tel: +61 3 9270 2556 Fax: +61 3 9417 5406 Mobile: 0414 691690 Next message: Peter Wein: "Re: Preeclampsia Lab Package" Previous message: RModugno@aol.com: "Re: +3/5 (Long)" In reply to: Malcolm Griffiths: "Re: OB: progesterone" Next in thread: Malcolm Griffiths: "OB: progesterone - reponse to Peter Wein!" Reply: Malcolm Griffiths: "OB: progesterone - reponse to Peter Wein!"

Return to

Mail a New Message to the Forum: ob-gyn-l@obgyn.net Forum Administrator: geffrey.klein@obgyn.net Report Technical Problems: webmaster@obgyn.net Last Updated: Wed Dec 2 05:24:28 2009

The American Medical Association is no longer designating CME hours for AMA Category II CME credit. However, physicians themselves may self designate learning activities as Category II CME credit hours if they feel it is of sufficient educational merit and meets the formal definitions of continuing medical education. OBGYN.net believes these interaction in this forum meets these criteria. For further information see the AMA web site.