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Re: Preeclampsia Lab PackageFrom: Malcolm Griffiths (Malcolm@MGRIFF22.demon.co.uk)Sat Jun 27 16:06:06 1998
In message <199806271533.KAA23835@ICSI.Net>, zygote@ICSI.Net writes > >I believe the Lancet had an article that clearly showed that the use of MgSO4 >was superior to the use od dilantin in pts with preeclampsia. I though that >article finally put to rest the disparate practices between the UK and the USA. >Apparently my assumption was wrong. You are quite wrong! The Lancet paper established that MgSO4 was superior to phenytoin and diazepam in secondary prophylaxis of eclampsia. That is they showed MgSO4 was the best way to stop a woman who'd fitted from having another fit. There are one or two of my colleagues who would even quibble about that (my favourite sceptic feels it may be wrong to extrapolate from the setting of the study to our own unit).
No study to date has really established that MgSO4 is superior to
placebo in pre-eclamptic women. Nor has any study established what level
of pre-eclampsia needs MgSO4. MAGPIE is an RCT which aims to do this. It
is being run by the same coordinator as the Lancet paper had (Lelia
Duley).
> --
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