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Re: REI:Pregnancy and Premature Ovarian FailureFrom: Peter Wein (p.wein@obsgyn-mercy.unimelb.EDU.AU)Thu Apr 30 20:55:30 1998
At 07:29 PM 30/04/98 -0500, you wrote: >At 12:38 AM 4/30/98 -0500, you wrote: >>Dear List: >> >>Advice wanted: >> >>31y/o G1P1001 hispanic female with a history of premature ovarian failure >>who transferred care to me at 23 weeks gestation and went on to deliver a >>viable female infant 12/97. > >You can expect to see up to 2-3% annual resolution of POF in younger women. >Resolution may follow a period of HRT or BCP's. You did not mention whether >this patient had a normal chromosome analysis. The presence of antiovarian >antibodies may select a population more likely to have spontaneous >resolution. Some of these patients see a resolution of POF with a burst >course of Medrol. We have seen a few who have normalized FSH levels and >undergone ovulation induction, yet no pregnancies yet in those who have >been so treated. > Another thing to consider as I have mentioned before in premature ovarian failure is fragile X syndrome - this won't be diagnosed on routine karyotype - need Southern blot or PCR looking for triplet repeat count.
-- Peter Wein Senior Lecturer Department of Obstetrics and Gynaecology University of Melbourne, Mercy Hospital for Women Clarendon Street, East Melbourne 3002 Australia Tel: +61 3 9270 2556 Fax: +61 3 9417 5406 Mobile: 0414 691690
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