Re: Sickle cell screening

From: ATB28 (ATB28@aol.com)
Sun Apr 12 22:09:20 1998


In a message dated 98-04-12 15:57:23 EDT, karennp@voyager.net writes:

<< Others say that the sickle cell prep test is unreliable, and that every black or mediterranean patient should have an automatic hgb. electrophoresis >>

There is about a 3% false negative rate among sickle cell heterozygotes (I can't locate the reference, sorry). As a result, we converted our protocol at Einstein about 5 years ago to hemoglobin elelctrophoresis in our at-risk populations. It had the additional benefit of helping us identifiy beta- thalassemia carriers.

Allan Bombard, MD





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