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Re: OB: Downs ScreningFrom: ATB28 (ATB28@aol.com)Thu Apr 2 21:29:52 1998
In a message dated 98-04-02 12:03:08 EST, gklein@bcm.tmc.edu writes: << Maternal blood tests taken during the first trimester of pregnancy can detect the majority of fetuses affected with Down's syndrome, >> This is old news for those who have kept up with events abroad, where screening for fetal chromosome abnormalities, including Down syndrome, using both biochemical and ultrasound has been available for some time now. The major problem as I see it, is the lack of a reliable first trimester biochemical screening test for fetal neural tube defects. Neither hCG nor PAPP-A facilitates detection of NTDs. Thus, second trimester screening is still necessary. How many patients, docs, and plans will reliably succeed in a 2-step model? It'll be interesting to follow the literature and clinical experience on this one! Allan T. Bombard, MD
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