Re: anovulation

From: Mark Perloe, M.D. (mperloe@ivf.com)
Mon Mar 30 04:19:25 1998


For patients with large ovaries and "necklace sign" or high levels of LH or high LH/FSH ratio 1-2 days after last clomiphene dose, other alternatives may be more cost effective.

Before initiating clomiphene, a brief clinical and/or laboratory evaluation is necessary. Cushing syndrome, POF, UOD (high day 3 FSH), non-classical CAH, thyroid and pituiary disorders must be considered. Frequently, insulin resistance is found in PCOS patients and may well respond to insulin sensitizing agents.

While three months of clomiphene therapy will not likely result in excess expense, initiating therapy before any evaluation may mask conditions that will predispose to miscarriage.

I wonder what others feel the minimum evaluation before considering clomiphene for anovulation ought to be.





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