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Re: MFM: NEJM article on Aspirin and pre-eclampsia From: Bernard Cristalli (bcrist@club-internet.fr) Sat Mar 14 12:14:54 1998 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Richard B. Kates, MD: "Re: MFM: NEJM article on Aspirin and pre-eclampsia" Previous message: Kelly Shanahan, MD: "Re: OB: PPROM at 19 weeks" Maybe in reply to: Geffrey H. Klein, MD: "MFM: NEJM article on Aspirin and pre-eclampsia" Next in thread: Malcolm Griffiths: "Re: MFM: NEJM article on Aspirin and pre-eclampsia" Reply: Malcolm Griffiths: "Re: MFM: NEJM article on Aspirin and pre-eclampsia" Low-Dose Aspirin to Prevent Preeclampsia in Women at High Risk 60 mg a day is not a low-dose aspirin but a *very* low dose. Studies that had shown an efficacy of aspirin were with 100 to 250 mg and it was not to prevent the disease but to prevent complications of the disease. The aim of this study is queer "Whether low-dose aspirin ... may reduce the incidence of the disease in women at high risk", it ought to be: "which is the lowest efficient dose of aspirin to prevent complications" The conclusions are not surprising with such a very low-dose. -- Geffrey H. Klein, MD wrote: > > This multicenter RCT seems to indicate that aspirin is not effective in preventing > pre-eclampsia. I am going to review this article for the OBGYN.net journal review. > However, I would like to get some input from the list.. > > Geff Klein, MD > gklein@icsi.net > > ___________ > > The New England Journal of Medicine -- March 12, 1998 -- Volume 338, > Number 11 > > Low-Dose Aspirin to Prevent Preeclampsia in Women at High Risk > > Steve Caritis, Baha Sibai, ... > > Abstract > > Background. Whether low-dose aspirin prevents preeclampsia is unclear. > It is not recommended as prophylaxis in women at low risk for > preeclampsia but may reduce the incidence of the disease in women at > high risk. > > Methods. ... The women were enrolled between gestational weeks 13 and 26 > and received either 60 mg of aspirin or placebo daily. ... > > Conclusions. In our study, low-dose aspirin did not reduce the incidence > of preeclampsia significantly or improve perinatal outcomes in pregnant > women at high risk for preeclampsia. (N Engl J Med 1998;338:701-5.) -- Bernard Cristalli MD CNGOF AIHP - ACCA Paris - France http://www.obgyn.net/corresp/cristalli.htm Next message: Richard B. Kates, MD: "Re: MFM: NEJM article on Aspirin and pre-eclampsia" Previous message: Kelly Shanahan, MD: "Re: OB: PPROM at 19 weeks" Maybe in reply to: Geffrey H. Klein, MD: "MFM: NEJM article on Aspirin and pre-eclampsia" Next in thread: Malcolm Griffiths: "Re: MFM: NEJM article on Aspirin and pre-eclampsia" Reply: Malcolm Griffiths: "Re: MFM: NEJM article on Aspirin and pre-eclampsia"

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